From blood samples of patients admitted to an intensive care unit in Limoges university hospital for a severe form of the coronavirus with organ failure(s), a research team from the university of Limoges, labeled by Inserm and CNRS, have investigated the consequences of infection on the white blood cells, or leukocytes.
These researchers from the unit “Control of the Immune Response B and lymphoproliférations” and the Center for clinical investigation* work normally on the immune response inappropriate for patients with cancers of B lymphocytes, or resuscitation in the face of a generalized infection, called sepsis.
The blood of 13 patients with severe reached analysed
At the end of march, they transferred their expertise in caring for the sick of the Covid-19. They have analyzed and followed over a one-week samples of 13 critically ill patients, intubated for respiratory distress and compared them with those of ten healthy volunteers.
“We wanted to determine where was the failure, what was modified in the different types of leukocytes,” explains Robin Jeannet, engineer hospital, who led the study.
Robin Jeannet is the lead author of a study analyzing the consequences of the Covid-19 on the white blood cells.
“We found that people were extremely lymphopenic : to be clear, he is falling deep in the number of lymphocytes, the white blood cells necessary for eradication of the virus, the stigma, cellular immunosuppression. “This situation creates a paradox, highlights Robin Jeannet” between the inflammation of the lungs and the weakening of the immune system in general “.
In order to help the patient to better defend themselves, one of the tracks would boost the immune system and thus to adapt the treatment. Results that would require a cohort of more broad to be confirmed.
(*) Respectively, led by professor John Steel and dr. Bruno François.