Dr. Minkyu Kim’s research team at the Korea Atomic Energy Research Institute’s Advanced Radiation Research Institute announced on the 20th that they had identified the principle that can control the pathogenicity by analyzing the structure of proteins involved in the expression of cholera toxin.
When infected with Vibrio, which causes cholera or sepsis, the protein transporting fructose increases.
The research team paid attention to the proteins HPr (phosphate transfer chain protein) and FruR (fructose transport protein activator) involved in the regulation of sugar metabolism to find the principle of suppressing fructose transport protein expression.
The changes in HPr and FruR phenomena were observed when glucose and fructose were present in the environment around cholera bacteria.
It is known that cholera bacteria prefer glucose to fructose, and in the presence of glucose, HPr and FruR bind and the fructose transport protein is not expressed. The same was true when glucose and fructose were present together.
On the other hand, when glucose was exhausted and only fructose was present, HPr and FruR were separated and the fructose transport protein was expressed.
The research team discovered the bonding method of HPr and FruR using ‘X-ray crystallography’, a type of radiation.
X-ray crystallography is a method of determining the atomic structure by analyzing the diffraction phenomenon that occurs when X-rays are irradiated on atoms.
“We have identified a phenomenon that can control the toxicity of bacillus cholera using X-rays,” said Byeong-yeop Jeong, director of the Advanced Radiation Research Institute.
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2023-04-21 02:19:54
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#Atomic #Energy #Research #Institute #Identification #principle #controlling #cholera #toxicity #Xrays #Sciencetimes
