Researchers at the University of Central Florida have created a digital map of the sympathetic nervous system. Using bioelectronics, the map aims to guide the treatment of cardiovascular conditions such as hypertension and heart failure by electronically stimulating nerves. The map could also aid further research into the functional role of specific nerves in the body.

The sympathetic nervous system (SNS) is a key component of the human nervous system, responsible for regulating certain bodily functions such as heart rate, blood pressure, and breathing. Despite its importance, there has not been a reliable and comprehensive map of the SNS – until now. Recently, researchers have announced the creation of the first ever digital map of the SNS, providing a new tool for understanding and treating a range of health conditions. In this article, we will explore the significance of this breakthrough, what it could mean for future research and treatments, and the challenges that still remain.


A team of researchers from the University of Central Florida College of Medicine in the US have created a digital topographical map of the cardiac sympathetic neural network. This region controls the body’s heart rate and its “fight-or-flight” response. The researchers hope that this map will eventually guide treatments for cardiovascular conditions using bioelectronic devices. The findings were published in Scientific Reports. These results suggest that the map may serve as a guide for treatments such as neuromodulation therapy, which is electronically stimulating nerves to treat cardiovascular conditions. The sympathetic nervous system plays a pivotal role in regulating cardiac functions, through an intricate network of nerves. It helps the body respond to dangerous or stressful situations. Once the body senses danger, it speeds up the heart rate, to deliver more blood to areas that need more oxygen. To create the map, the team used a combination of state-of-the-art techniques that included imaging, tracing, digitising and quantitatively mapping the distribution of the sympathetic nervous system, including the heart’s whole atria and ventricles. The researchers created an in-depth 3D map of a rodent heart’s intrinsic nervous system. The system, known as the “little heart brain”, contains thousands of neurons around the heart that regulate heartbeat and blood circulation. Their latest project extended that study and mapped a topographical network of the nerves in the sympathetic nervous system and its connection to the heart. The team hopes the advanced blueprint will help scientists and physicians study the brain-heart connection and navigate more precise control of different heart regions, including those that control the heartbeat. This mapping goes beyond what can be found in a textbook. It is a digitised brain-heart atlas that will be interactive. The researchers hope it will serve as a guide not only for scientists and physicians, but also for students, as they learn the neuroanatomy of the heart. The ground-breaking part of this project is the precision at which the mapping is completed at the microscopic level, allowing us to see the single cells and single nerve axons. This is the first time that scientists will see the whole organ at such an intricate level. The researchers believe that this map will help scientists better study the functional role of specific nerves by activating or deactivating them and observing their impact on the body. The mapping can also serve as a guide for treatments such as neuromodulation therapy, which electronically stimulates nerves to treat cardiovascular conditions, such as hypertension, sleep apnoea and heart failure. The use of this map as a sympathetic-cardiac atlas opens the door for innovative therapies for several cardiovascular diseases and nerve-related disorders and avoids side effects associated with many pharmaceuticals.


In conclusion, the creation of a new digital map of the sympathetic nervous system is an exciting development in the field of neuroscience. This comprehensive visualization of the complex network of nerve fibers that control our body’s response to stress and other stimuli has the potential to improve our understanding of a range of physical and mental health conditions. Whether it is anxiety disorders, chronic pain, or cardiovascular disease, this new tool has the potential to help researchers and medical professionals identify new treatments and therapies to help those who suffer from these conditions. As we continue to unravel the mysteries of the human brain and nervous system, this amazing new technology promises to be a valuable tool in the quest for better health and wellbeing for all.