15 bullet highlights:
Direct oral anticoagulants (DOACs) are associated with a reduced risk of dementia in patients with atrial fibrillation, particularly in Asian populations. DOACs were associated with a lower risk of dementia compared with warfarin in the overall cohort. Among Asian patients, DOACs were associated with a more significant reduction in dementia risk. The DOACs dabigatran, apixaban, and rivaroxaban were associated with a reduced risk of dementia compared with warfarin. The use of DOACs in atrial fibrillation significantly reduces the risk of dementia, especially in Asian patients. Data on reversal of this benefit with increasing age suggest the need for further study. Asian patients are more likely to be allergic to vitamin K receptor antagonists, which can lead to bleeding events leading to the development of dementia or a reduction in warfarin dosage to subtherapeutic levels. Compared with warfarin, DOACs can exert super-effective effects at standard doses. DOAC use in atrial fibrillation significantly reduces dementia risk. Asian patients saw the greatest benefits in dementia reduction. The benefits of DOACs may be reversed with increasing age. DOAC use in patients with atrial fibrillation does not increase the risk of bleeding. DOAC use in patients with atrial fibrillation is associated with a reduced risk of atrial fibrillation-related stroke. DOAC use in patients with atrial fibrillation reduces the risk of all-cause death. DOAC use in patients with atrial fibrillation is not associated with the risk of myocardial infarction and other coronary events.
in conclusion:
The use of direct oral anticoagulants (DOACs) in patients with atrial fibrillation reduces the risk of dementia, particularly in Asian populations. DOACs can replace warfarin without increasing the risk of bleeding, making them a better choice for patients with atrial fibrillation. However, the benefits of DOACs may reverse with age and further study is needed.
2023-09-11 21:37:46
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