“Women with BRCA-1 breast cancer mutation gene, risk of death reduced through MRI surveillance.”
(Seoul = Yonhap News) Reporter Han Seong-gan = Among the breast cancer mutant genes (BRCA1 or BRCA2) that significantly increase the risk of breast cancer, a study showed that women with BRCA1 can significantly reduce the risk of breast cancer death through MRI surveillance.
Dr. Teresa Cajal’s research team from the Clinical Oncology Laboratory at the Sant Pau Institute in Barcelona, Spain, studied BRCA1 in 59 medical centers in 11 countries (United States, Canada, Poland, Norway, Israel, Italy, Austria, Netherlands, France, Spain, and Bahamas). Medical Express reported on the 4th that this was revealed as a result of a comprehensive analysis of research data on 2,488 women with the BRCA2 mutation gene (average age at the start of the study, 41.2 years).
Of the total study subjects, 2,004 people had the BRCA1 mutation gene and 484 had the BRCA2 mutation gene.
Of these, 1,756 (70.6%) received an average of 4.7 MRI scans for breast cancer surveillance, and 732 (29.4%) did not. 1,365 people underwent MRI examinations more than twice, with an average of 0.95 years between examinations.
Among the women participating in the MRI surveillance program, 1,442 women had the BRCA1 mutation gene and 314 women had the BRCA2 mutation gene.
Overall, during an average follow-up period of 9.2 years (maximum 24 years), 344 patients (13.8%) were diagnosed with breast cancer and 35 patients (1.4%) died from breast cancer.
Among the 1,756 women who participated in the MRI surveillance program, 241 were diagnosed with breast cancer and 14 died from breast cancer.
Among the women (732) who did not participate in the MRI surveillance program, 103 were diagnosed with breast cancer and 21 died from breast cancer.
Considering other variables such as age, the breast cancer mortality rate of women who participated in the MRI surveillance program was found to be 77% lower than that of women who did not participate in the MRI surveillance program.
In particular, the BRCA1 mutant gene group had an 80% lower breast cancer mortality rate. The BRCA2 variant gene group had a 13% lower rate.
The group that participated in the MRI surveillance program had a 78% lower breast cancer mortality rate than the BRCA mutation group that had received mammograms to diagnose breast cancer.
The research team explained that these results show that an MRI surveillance program can significantly reduce the risk of breast cancer death, especially in women with the BRCA1 mutation gene.
The research team pointed out that this is because MRI surveillance can detect breast cancer at an early stage when maximum treatment effect can be achieved.
BRCA1 and BRCA2 mutant genes have long been known to significantly increase the risk of breast cancer.
The U.S. Centers for Disease Control and Prevention (CDC) estimates that women with the BRCA mutation gene have a 50% chance of developing breast cancer by the age of 70.
The American Cancer Society (ACS) says that women with BRCA mutations have up to a 70% chance of developing breast cancer by the age of 80.
Individual studies have shown that the risk of breast cancer in BRCA mutant genes can increase by up to 85% by age 70.
The results of this study were published in the latest issue of JAMA Oncology.
skhan@yna.co.kr
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Hansunggan
2024-03-05 01:24:03
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