Recently, as coronavirus variants have begun to spread again, domestic researchers have developed a drug that prevents the virus from entering the human body.
Professor Myung Kyung-jae’s research team in the Department of Biomedical Engineering at the Ulsan National Institute of Science and Technology (UNIST) announced on the 7th that they had developed ‘UNI418’, a compound that inhibits has entered the coronavirus. The research team explained that this compound regulates genome homeostasis and prevents viruses from entering the human body.
Coronaviruses enter human cells through the process of endocytosis, in which foreign substances are absorbed. The research team revealed that inhibition of proteins called ‘PIKfyve’ and ‘PIP5K1C’ during this process can prevent viral attack by maintaining genome homeostasis.
Genomic homeostasis is a biological system that safely protects genetic information and makes it available when needed. The research team proved that ‘UNI418’ helps genome homeostasis while preventing the infiltration and proliferation of coronaviruses into cells.
The research team explained that this study is the first to show that the viral infection process can be stopped step by step, and that it shows the possibility of leading to a new virus treatment.
Co-researcher Dr. Kim Mi-hyeon of the Korea Research Institute of Chemical Technology said, “UNI418 has a high potential to be developed into a new treatment that can prevent a variety of viral diseases. “
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2024-08-07 01:10:48
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