Women at high risk of venous thromboembolism in the context of oral contraceptive (OC) use could be identified using a polygenic risk score (PRS), according to a study published in the American Journal of Obstetrics & Gynecology.
Polygenic evaluation may detect additional risk of venous thromboembolism that is not captured by investigation of genes commonly associated with hereditary thrombophilia. The use of oral contraceptives significantly increases the risk shortly after initiation of use, but it decreases with continued use.
Main results:
Without assessing genetic risk, the risk of venous thromboembolism was found to be increased during the first 2 years of CO use, but not during continued use When genetic risk was taken into account, women in the highest PRS category had an increased risk of developing venous thromboembolism in the first 2 years of CO use Carriers of factor V Leiden and prothrombin genetic variants had an increased risk of venous thromboembolism Highest risk of developing venous thromboembolism in the first 2 years of CO use was detected in women with elevated PRS who were carriers of factor V Leiden and prothrombin genetic variants
Worldwide, more than 150 million women use oral contraceptives. CO consumption is associated with a 3-5 times increased risk of venous thromboembolism due to excess estrogen hormones. Women with hereditary thrombophilia or carriers of certain genetic variants, such as those in the genes encoding factor V Leiden and prothrombin, are at increased risk of venous thromboembolism.
The study included the data of almost 250,000 people from UK Biobank. The effect of CO use in the first 2 years and the remaining years of oral contraceptive use on the risk of venous thromboembolism was estimated. Study participants were stratified according to their polygenic risk scores and whether they carried factor V Leiden and/or prothrombin genetic variants.
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2023-11-22 10:38:21
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