Katarzyna Dziubek, a PhD scholar from the Worldwide Heart for Most cancers Vaccine Analysis on the College of Gdańsk, acquired a grant from the Kościuszko Basis. As a part of the grant, he’ll endure a six-month analysis internship within the Schatton laboratory at Harvard Medical Faculty.
The analysis group through which M.A. will participate within the analysis internship Katarzyna Dziubek, was the primary to indicate that the PD-1 immunoreceptor, an immune checkpoint focused in most cancers immunotherapy, is current not solely on immune cells but in addition on melanoma most cancers cells. Their examine additionally indicated a doable affect of intracellular expression of the PD-1 protein in tumor cells on the response to immunotherapy in most cancers sufferers, proving that the mechanism of immunotherapy is extra complicated than initially assumed.
– Throughout my doctoral undertaking, I investigated the affect of PD-1 protein signaling on molecular pathways and interactions between PD-1 proteins in a mobile mannequin of osteosarcoma (a kind of bone most cancers). Because of establishing this cooperation, I will proceed the analysis I’ve began, based mostly on my outcomes up to now – says Katarzyna Dziubek, M.A. Dr.’s laboratory Schatton is very specialised within the subject of glycan mass spectrometry and analysis on protein glycosylation (the method of attaching sugar residues) as a kind of their post-translational modification, which is changing into more and more essential within the context of most cancers development and invasion. – In my work, I may also use this laboratory’s experience in CRISPR-based mutagenesis, and analysis on the most cancers PD-1 protein will probably be carried out each in vitro and on scientific samples. At present, few analysis teams are investigating the significance of the PD-1 receptor within the context of most cancers itself, and cooperation with one in every of them, which can be a pioneer of such analysis, will give me an amazing alternative to develop the undertaking I’m engaged on. I’m satisfied that this journey will probably be an incredible skilled and private expertise, and I hope that this internship will lead to long-term cooperation with scientists from Harvard Medical Faculty – provides the doctoral scholar.
The change program with the USA, financed by the Kościuszko Basis, permits Polish scientists to use for scientific and creative tasks carried out at American universities. The Basis awards grants and internships with a complete worth of over PLN 600 million. {dollars} to about 40 scientists per yr.
