Start in the country last phase of the clinical trial of one of the two influenza vaccines developed with mRNA, the same platform as the latest vaccines for Covid-19 that entered the country. It is estimated that in Argentina they will participate in the new study between 1,500 and 2,000 people over 65 years of agewhile in the United States, research in young adults is advancing.
“Vaccines against respiratory viruses have always had relatively low efficacy compared to the new platforms, but it is useful for public health strategies to protect the vulnerable population. Now, it aims to have vaccines with more efficacy and rapid adaptation [a las cepas circulantes] every year. It’s a new generation of vaccines,” he said. Gonzalo Perez Marcprincipal investigator of the study that begins in the Central Military Hospitalalong with several other centers in the Buenos aires city and one in At payment.
In this case, it is the laboratory’s candidate seasonal flu vaccine. Pfizer. The first with an mRNA platform to be tested in phase III –prior to the request for regulatory approval for its commercialization– was the immunizer of Modern: In people over 18 years of age, it demonstrated efficacy against circulating strains of influenza A, but not B, for which reason the laboratory reported last February, when communicating the results, that it would adjust the product to improve the immune response.
Pérez Marc explained that, during the clinical trial that is beginning with the enrollment of volunteers, one group will receive the vaccine under evaluation and another, a quadrivalent vaccine already on the market. The study design envisions that participants and researchers do not know until the end of the process who was randomly assigned to one or the other vaccine.
Gonzalo Pérez Marc, principal investigator of the clinical trial that begins at the Central Military Hospital and other centers in the city of Buenos Aires and La PlataPatricio Pidal/AFV
It is a study in which the new product will be compared with an already available flu vaccineand. The objective is to determine if the effectiveness it is the same as a product already approved and in use; if it induces the immune system to produce the same amount of antibodies against the circulating strains of the influenza A and B virus”, added the pediatrician, who is the principal investigator of the Military Hospital and general director of Equipo Ciencia, which coordinates the study.
The requirements to be a volunteer are not many and include being in good general health, without an acute illness or an unstable or uncontrolled chronic condition. Nor do you have to be vaccinated against the flu this year, but you do want the annual dose. Interested parties can register at https://www.equipociencia.com.
“The population over 65 years of age was greatly affected by the Covid-19 while there were no vaccines and, later, with the Covid prolongedwith which the focus in the world in the coming years is placed on this population, which at the same time has gained a better quality of life and can be offered protection through vaccination”, anticipated Pérez Marc. “Respiratory virus infections they greatly influence cardiovascular complications and morbidity and mortality,” he added, by way of example.
He anticipated, at the same time, that in the first half of next year progress could already be made with the trial of the combined vaccine to influenza, SARS-CoV-2, and respiratory syncytial virus (RSV), which are currently co-circulating.
In this triple circulation scenarioas LA NACIÓN has been publishing, cases of flu are beginning to displace RSV infections, with a small increase in SARS-CoV-2 infections, according to the testimonies of professionals in hospitals in the Buenos Aires metropolitan area (AMBA) and positive results for respiratory viruses under surveillance in designated monitoring units in health centers in the provinces.
Almost a third (32%) of the samples from outpatients studied for the three viruses in those units tested positive for influenza in the week of June 25 to the 1st of this month, according to the epidemiological report of the Ministry of Health of the Nation of this last weekend.
Specialists and health authorities agree in recommending at this time that people with respiratory symptoms do not go to work, school or public placesGetty Images
These three viruses alone are already causing more than half (52.5%) of respiratory infections. There are also cases of respiratory disease due to metapneumovirus, parainfluenza and adenovirus.
To this, the national health authorities added a public warning for a increase compared to previous years in detected cases of invasive infections by the bacteria Streptococcus pyogenesbest known for causing pharyngitis, angina, or scarlet fever. In this case, this alert is not for these pictures, but for 118 cases of invasive forms of disease that the same bacteria can cause – such as meningitis, among others – without adequate and timely detection and antibiotic treatment.
In this regard, the Argentine Society of Pediatric Infectious Diseases (Sadip) yesterday issued a statement for health personnel in the face of “data from different health centers and the concern of the [profesionales] due to the increase in cases of streptococcal infections.
In its recommendations, which are more oriented towards pediatric care, the entity explains that invasive disease due to S. pyogenes it is more frequent “as a complication of a previous skin and soft tissue infection (such as chickenpox, surgical wound infection, etc.), while pharyngitis as a gateway to invasive disease occurs in less than 20% of cases.”
At this time of year, with the increase in consultations for respiratory causes, Sadip advises suspecting pharyngitis from S. pyogenes to perform a rapid test or diagnostic swab for children three years of age or older, especially school-age, with the following symptoms: sore throat and/or difficulty swallowing, fever, headache, abdominal pain, nausea, and vomiting; redness and swelling of the throat, tonsils, or uvula; petechiae on the palate, exudate from the pharynx/tonsils, swollen glands in the neck or adenopathies, and the appearance of a scarlet fever-like red rash on the body.
Conocé The Trust Project
2023-07-11 17:28:00
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