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Study: Exposure to toxic ‘forever chemicals’ during pregnancy increases …These findings are vital to understanding the potential risks posed by prenatal exposure to environmental chemicals like PFAS. A 2020 study highlighted the impact of PFAS exposure during pregnancy, raising concerns about the rates of maternal disease as well as long-term consequences for both the developing fetus and the child’s future health.URL: https://www.ewg.org/news-insights/news/2023/07/study-exposure-toxic-forever-chemicals-during-pregnancy-increases-odds
PFAS exposure during pregnancy: Implications for placental health and … pregnancy PFAS levels were associated with placental parameters of fetal-maternal exchange, highlighting their broad physiological impacts. Graphical abstract…. No human studies have explored the impact of PFAS on placental histology, but Chowdhury et al. investigated arterial vasculature of placental fetal surface in 175 term placentae …
URL: https://www.sciencedirect.com/science/article/pii/S0160412025000595
Per- and polyfluoroalkyl substances exposure during pregnancy and … Here,we conducted a systematic review and meta-analysis to 1) review the evidence on the impact of pregnancy PFAS exposure on diseases of mothers or their offspring and 2) quantificationally assess the association of maternal blood-specific fluorinated… network of the fetus, allow feto-maternal exchanges. This phenomenon could cause a decrease in exchanges and a lower oxygen and nutrients from the mother to the fetus.
According to previous studies, deregulation in fetal-maternal exchanges are associated with intrauterine growth delays and the growth of preeclampsia, explains Nadia Alfaidy, research director at Inserm and co-deeper with this study. As a reminder, preeclampsia is characterized by high blood pressure and a significant presence of proteins in the urine. This syndrome can cause many complications if it is not properly treated.Another revelation: women who present the concentrations of seven PFAS, which researchers have been able to determine, have a low-weight placenta than other women. “Though, several studies suggest that a decrease in the weight of this organ may indicate that its functions are compromised, affecting the development of the fetus” notes the Inserm in a press release.
“We hope that a national study will be born shortly to better understand the consequences of exposure to PFAS on the health of the mother and the child” adds Claire Philippat.
Source: INSERM, ANSES, Ameli.fr
The Impact of PFAS Exposure During pregnancy: An Interview with Dr. Nadia alfaidy
Table of Contents
Recent studies have highlighted the potential risks of exposure to toxic “forever chemicals,” known as PFAS, during pregnancy. These findings are crucial for understanding the long-term health implications for both mothers and their developing fetuses. In this interview, the Senior Editor of world-today-news.com sits down with dr. Nadia Alfaidy, a specialist and research director at Inserm, to discuss the implications of PFAS exposure on placental health and fetal growth.
Understanding PFAS and Their Impact on Pregnancy
Editor: Can you start by explaining what PFAS are and why they are considered a concern,especially during pregnancy?
Dr. Nadia Alfaidy: PFAS, or per- and polyfluoroalkyl substances, are a group of man-made chemicals that have been used in various industrial and consumer products. They are often referred to as “forever chemicals” because they do not break down naturally in the environment. Exposure to PFAS during pregnancy can have significant health implications for both the mother and the developing fetus. Recent studies have shown associations between PFAS exposure and increased rates of maternal disease, and also long-term consequences for the child’s health.
PFAS and Placental Health
Editor: What are the implications of PFAS exposure on placental health?
Dr. Nadia Alfaidy: The placenta plays a critical role in fetal-maternal exchange, facilitating the transfer of oxygen and nutrients from the mother to the fetus.Studies have shown that PFAS levels are associated with placental parameters, indicating their broad physiological impacts. Our research has explored the arterial vasculature of the placental fetal surface in term placentae, revealing potential disruptions in these vital exchanges. Deregulation in fetal-maternal exchanges can lead to intrauterine growth delays and the development of preeclampsia, a condition characterized by high blood pressure and proteinuria, which can result in serious complications if not properly managed.
Assessing the Impact on Fetal Development
Editor: How does PFAS exposure affect fetal development?
Dr. Nadia Alfaidy: Exposure to PFAS during pregnancy can lead to compromised placental function, as evidenced by lower placental weights in women with higher concentrations of these chemicals.A decrease in placental weight suggests that its functions may be impaired, possibly affecting fetal development. Our systematic review and meta-analysis quantified the association between maternal blood-specific fluorinated substances and the health of mothers and their offspring.We found that deregulation in fetal-maternal exchanges, which can be caused by PFAS exposure, is associated with adverse outcomes such as intrauterine growth delays and preeclampsia.
looking Ahead: The Need for further Research
Editor: What are the next steps in understanding the consequences of PFAS exposure on maternal and child health?
Dr.Nadia alfaidy: We hope that a national study will soon be initiated to better understand the consequences of PFAS exposure on maternal and child health. This will allow us to gather more comprehensive data and develop strategies to mitigate the risks associated with these chemicals. Our findings highlight the need for further research and public health interventions to protect pregnant women and their children from the harmful effects of PFAS.
Conclusion
Editor: Thank you, Dr. Alfaidy,for providing valuable insights into the impact of PFAS exposure during pregnancy.Your work is crucial for raising awareness and promoting policies that protect maternal and child health.
Dr. Nadia Alfaidy: Thank you for having me.It’s essential to continue studying these issues and advocating for better environmental policies to safeguard the health of future generations.