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12-month neurological and psychiatric outcomes of semaglutide use for…
The observation that semaglutide use was associated with lower risks of cognitive deficits and, to some extent, dementia than the DPP4I sitagliptin and the sulphonylurea glipizide, but a similar risk compared to the SGLT2I empagliflozin aligns with a recent network meta-analysis showing that SGLT2Is and GLP1-ras rank better than DPP4Is and sulphonylureas in terms of cognitive outcomes and …
Ozempic Shows Potential in lowering Alzheimer’s Risk
Summary: New research suggests that semaglutide, a popular diabetes and weight-loss drug, may reduce the risk of Alzheimer’s disease in people with type 2 diabetes. The study compared semaglutide to seven other anti-diabetic drugs and found it was linked to a considerably lower risk of developing Alzheimer’s.
Ozempic Linked With Lower Risk of Alzheimer’s Diagnosis
Source reference: Wang W, et al “associations of semaglutide with first-time diagnosis of Alzheimer’s disease in patients with type 2 diabetes: target trial emulation using nationwide real-world …
One recent analysis found that, over the course of three years, people taking semaglutide (the compound in Ozempic and the weight loss drug Wegovy) were about 40 to 70 percent less likely to be diagnosed with Alzheimer’s disease compared with people on other diabetes medications.
A paper published this month reviewing a Veterans Affairs database similarly found that people prescribed these drugs were less likely to develop dementia compared with those who took other diabetes drugs. The benefit was more modest, though, with a roughly …
Promising Findings: Ozempic and Alzheimer’s Disease
Recent studies have sparked hope in the medical community regarding the potential of Ozempic, a medication primarily used for diabetes management, in delaying the progression of Alzheimer’s disease. According to a study, patients using Ozempic (semaglutide) showed a 10 percent decreased risk of developing dementia compared to those not on the drug.
The findings seem promising. However, because these studies are observational, “it’s really hard to tell” whether the drugs are directly causing that benefit, or whether that lower risk is more of a coincidence, said Dr. Ziyad Al-Aly, the chief of research and progress at the Veterans Affairs St. Louis Healthcare System and an author on the study.
There are also clinical trials testing whether the drugs can treat people already diagnosed with dementia. Preliminary findings from one study of about 200 patients were presented at an Alzheimer’s association meeting last summer. They showed that patients with mild Alzheimer’s disease who received an older, similar medication (liraglutide, sold under the brand name Victoza), had slower declines in both their cognition and brain volume compared with patients who received a placebo.The benefits were modest, and the researchers couldn’t say whether they would meaningfully change a patient’s condition. But Dr.Paul edison,a professor of neuroscience at Imperial College London who led the trial,said that he was “encouraged” by the results.
Other trials testing whether semaglutide can delay the progression of Alzheimer’s disease are ongoing. these studies aim to provide more definitive evidence on the potential benefits of these drugs in combating neurodegenerative diseases.
How the Drugs Might work
Researchers don’t know how drugs like Ozempic might protect against neurodegenerative diseases — actually, they’re still trying to understand how these drugs impact the brain overall. But they have a couple of theories:
They Improve Metabolic Health
diabetes and obesity both increase a person’s odds of developing dementia, so it’s possible that the drugs reduce that risk by improving metabolic health. The two conditions are associated with increased inflammation in the body, and many scientists think that reducing inflammation is at least partly how the drugs improve other health conditions, including heart and kidney disease. The same dynamic might potentially be happening in the brain: Inflammation can kill cells and contribute to neurodegenerative disease,and these drugs may help by reducing it.
There is some evidence from animal studies that the drugs can suppress brain inflammation.
Summary of Findings
| Study | Findings |
|————————–|—————————————————————————————————-|
| Observational Studies | Patients using Ozempic showed a 10 percent decreased risk of developing dementia. |
| Clinical Trials | Preliminary findings suggest that similar medications slow cognitive decline in Alzheimer’s patients. |
| Theories | improve metabolic health, reduce inflammation, suppress brain inflammation. |
Conclusion
While the initial findings are encouraging, more research is needed to fully understand the mechanisms and potential benefits of Ozempic and similar drugs in treating and preventing Alzheimer’s disease. Ongoing clinical trials will provide more definitive answers in the coming years.
For more details on the ongoing trials and the latest research, visit the Alzheimer’s Association and ClinicalTrials.gov.
Stay tuned for further updates on this promising area of medical research.The text discusses the potential of certain medications,specifically those used for weight loss and diabetes,in preventing or treating Alzheimer’s disease. Here are the key points:
- Exenatide (Byetta): This drug can access deeper parts of the brain, including the hippocampus, which is damaged early in Alzheimer’s. Other drugs like semaglutide and liraglutide have mixed results in penetrating the blood-brain barrier effectively.
- Tau Protein Reduction: Some studies in mice have found that these medications can reduce the buildup of tau protein in the brain, a key contributor to Alzheimer’s. However, previous attempts to target tau have had mixed results.
- Multiple Mechanisms: The drugs likely work through multiple mechanisms, not just insulin resistance. This could contribute to their potential benefits.
- Potential Benefits: If these drugs can be repurposed to prevent or treat dementia, it would be a significant addition to the current treatments for Alzheimer’s, which are limited.
- Future Research: More research is needed to understand the exact mechanisms and potential benefits of these drugs in the context of Alzheimer’s disease.
The text also includes links to studies and articles for further reading.
