[건강이 최고] Severance Hospital, one-year treatment progress analysis results
Research results have shown that deep brain stimulation performed on patients with Tourette syndrome, a brain disease in which motor tics and vocal tics appear simultaneously, showed excellent results in both safety and effectiveness.
A research team led by professors Kyeong-won Jang and Jin-woo Jang (neurosurgery) at Severance Hospital, Jeong-han Lee (department of psychiatry), and Dong-ho Song (professor emeritus at Yonsei University) analyzed the one-year treatment progress of 20 patients with intractable Tourette syndrome who received deep brain stimulation at Severance Hospital since 2016. It’s the result.
This study is the first clinical study on deep brain stimulation for Tourette syndrome conducted in Korea, and the results were published in the international journal ‘Psychiatry and Clinical Neurosciences (IF 11.9).’
Tourette syndrome is a brain disease characterized by instantaneous actions or sounds in everyday life, regardless of one’s will. In general, it is often accompanied by behavioral and emotional disorders such as attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder, sleep disorders, and anxiety.
It is known that symptoms of Tourette syndrome are usually alleviated as children pass through adolescence and become adults, but about 20% of patients may experience more severe symptoms in adulthood.
Among them, if the condition does not improve even after sufficient pharmacological and non-pharmacological treatment, it is classified as intractable Tourette syndrome.
Deep brain stimulation is one of the main treatments applied to intractable Tourette syndrome. Deep brain stimulation is a treatment that restores damaged circuits to electrical action by inserting electrodes deep into the brain. Electrical stimulation is generated by installing a stimulation generator under the skin of the chest and connecting wires and electrodes deep into the brain. Because electrodes are inserted into very small nerve nuclei of about 5 to 6 mm, very sophisticated surgery is required. In Korea, a team led by professors Dong-ho Song and Jin-woo Jang has been conducting treatment since 2016.
The research team analyzed the one-year treatment progress of 20 patients with intractable Tourette syndrome who received deep brain stimulation at Severance Hospital since 2016. Using the ‘Yale Tic Symptom Rating Scale (YGTSS)’, the patient’s tic symptoms and other symptoms (obsession, depression, anxiety) were evaluated at 3-month intervals for 1 year.
As a result of the analysis, 11 out of 20 patients (55%) showed symptom improvement of more than 25% 3 months after surgery. Among them, symptom improvement of more than 35% was confirmed in five patients. One year after surgery, 12 out of 20 patients showed symptom improvement of more than 35%. There were only two patients who showed less than 10% effectiveness after surgery.
In particular, the five patients who showed a treatment effect of more than 35% within 3 months after surgery showed better treatment results compared to other patients even one year after surgery.
Symptoms such as obsession, depression, and anxiety did not significantly affect the postoperative effect, and all 20 patients had no surgical complications for one year.
Professor Jang Jin-woo said, “It is the first and largest single medical institution treatment outcome report in Korea, the first in Asia, and one of the best clinical research levels in the world.” “We will work harder together.”
Daeik Kwon Medical reporter dkwon@hankookilbo.com
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2023-11-12 03:47:50
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