News Like Information – ‘Dr. Teerawat’ lectures from the stomach to the head, deciding the fate of ‘demented brain’

‘Doctor Teerawat’ lectures from stomach to head, deciding the fate of ‘demented brain’

26 November 2023 Prof. Dr. Teerawat Hemajutha, Head of the Emerging Disease Health Science Center Faculty of Medicine Chulalongkorn Hospital Posted a message via Facebook “Thirawat Hemachudha Thiravat Hemachudha” as follows…

From the stomach to the head…determining the fate of dementia

People are born with a destiny predetermined by their genetic code. And how quickly the results of destiny will appear clearly, clearly and quickly during life. There are still important factors. that we can control

Dementia speaking now Whether it is memory impairment like Alzheimer’s et al (with other names), Parkinson’s disease et al. and degeneration in other nervous systems, such as in the spinal cord It is now considered to have arisen from the same root cause. is the presence of a twisted protein, so it is called misfolded protein and is caused by the instability of the balance controlling the formation Management and excretion of circulating proteins This causes abnormalities in the proteostasis system and, of course, inflammation is an important variable causing all of these dementias to be considered neuroinflammatory diseases.

Our refusal to receive an inheritance You may not be able to do it, but you may be able to open your will a little later, or even those who have already had the disease emerge, they can delay the disease by The saying goes “We can eat whatever we want.”

and at present must include that “We can breathe anything in like that,” that is, all chemical pollution in food, in drinking water, in the air that contains chemicals. There are substances that come from contaminated garbage. They are all bad guys that cause inflammation.

Exposure to air with 2.5 micropollutants for a short period of time causes a marked increase in the buildup of these twisted proteins and inflammation, leading to heart and brain atherosclerosis. and cancer as well

Foods that cause inflammation are: Foods with a lot of starch, sugar, sugary foods, red meat from animals that walk on land Meat that has been marinated, seasoned or kept for a long time, and even chicken, is also in this group. And it leads to having to approach vegetarians who are heavy on vegetables, fruits, and fiber that are eaten whole. And it’s chemical-free. It’s heavy on beans, but not a lot of soybeans. Shrimps, crabs, fish, shellfish shouldn’t be much. Cigarettes are prohibited. Healthy amounts of liquor But if you approach vegetarianism, you can eat several egg yolks per day.

These foods are forbidden. Modified by bacteria in the intestines It causes inflammation to enter the bloodstream and penetrate into the cerebral blood vessels and into brain cells. A second flare-up of inflammation occurs in brain cells and stimulates the production of even more of these twisted proteins. In addition, inflammation It also stimulates cells in the intestines. To create these twisted proteins Up along nerve number 10 and into the brain. And air pollution may explain the abnormal protein found in the first cranial nerve. distributed in the tissues of the nasal cavity and finally up into the brain

When the disease has already appeared Healthy dietary ingredients such as fish oil that contain EPA and DHA begin to degrade. This is because fish oil obtained from food must be converted by the liver. It’s a microscopic fish oil called plasmalogen. And then this microscopic oil is passed into the blood vessels of the brain, into the brain tissue, and into the cell surface and into different types of cells in the brain. But when the disease is already visible, All of these miniaturization and delivery processes are defective. Make it a tool to explain that Fish oil can help prevent symptoms in the early stages. All dementias have an incubation period of at least 10 to 15 years before symptoms appear.

Scientific evidence published on October 20, 2020 in the journal cellPress Cell Reports Medicine highlights the importance of visualizing dementia. It’s not just looking at the brain, but looking at the whole picture. This is because hormones in the blood that come from the intestines called gut hormones, such as the one called ghrelin, play a role in regulating the creation of new cells or stem cells in the adult human brain. And even though we’re old, it’s called neurogenesis.

The hormone comes in two forms: acyl-ghrelin (AG) and unacylated- ghrelin (UAG).

It was found that UAG turned out to be a villain, reducing or obstructing Creating new cells has been proven to cause abnormalities in current memory or short-term memory storage and the coordinated work of neurons in the same and different systems. (neuroplasticity) is not normal

Especially in sick people who have symptoms of Parkinson’s disease. combined with memory loss It has been found that there is an abnormality in this ratio between AG and UAG and confirmed by either testing in vitro or in animals that have been genetically modified to not have it. ghrelin-O-acyltransferase And without AG, there will be abnormalities in the memory system. When AG is given, it returns to normal. And they found clear evidence that AG, which helps create new cells, was blocked by UAG.

AG and UAG’s findings have also been tested in people with Parkinson’s who also have memory loss (parkinson’s -dementia), but how does it explain the phenomenon of other names for dementia? There may need to be further testing. But the important thing is that it paves the way. both in diagnosing people who may not yet have symptoms or whose symptoms are not yet clear until planning for the development of innovations and new medicines

There is information related to AG, previously reported in the journal Current Biology on September 17, 2020. It was found that this hormone tells the brain that it feels hungry. Through nerve number 10, which is a single nerve. Where proteins that twist and cause dementia serve as a passageway from the gut up to the brain.

and in laboratory animals where this signal transmission is abnormal It will be as if you have forgotten that you have eaten it. Make you eat and eat again. It’s like not eating enough. And it may explain what we see in many people with dementia who forget they’ve eaten and continue to eat. (Many of us probably use this excuse that there are few hormones but the truth is gluttony) which is part of the current memory (episodic memory) and in laboratory animals it It may be related to darkness – light or compared to day and night as well.

In general, having good health can be controlled from ourselves. This requires promoting awareness of how to behave, how to live in the matter of food and eating, and working together to promote clean air and safe food. Thai people will survive with the gold card only if we are not surrounded by full-blown diseases and full hospitals. Until there are doctors, nurses, equipment Modern innovations in cancer medicine Until the targeted drug costs 230,000 baht per injection, a set of four injections. If you extend your life for half a year or a year, you probably won’t survive. You have to think about solving the problem at the root cause, not chasing after the problem. /////////-005