A paper has been published showing that the administration of longevity protein ‘Clot’ improves cognitive function. invincible_bulldog/Courtesy of Getty Imagebank.
Research has shown that monkeys given longevity protein improved their cognitive function. If people close to primates are given this protein, it is expected to help prevent brain aging.
A research team led by Denna Duval, a professor of neurology at the University of California, San Francisco (UCSF) School of Medicine, reported on the 4th in the international journal Nature Aging that cognitive function improved after just one administration of the longevity protein ‘Klotho’ to old monkeys. Disclosed.
Cognitive function means almost all functions that the brain can do, such as remembering, focusing, and learning. As we age, our brain ages and our cognitive functions decline, which can lead to declines in memory, judgment, and language skills. If the degree is severe, daily and social life will reach a level of difficulty.
Cognitive function declines further when age-related brain diseases occur, such as Alzheimer’s disease. As the aging population is increasing worldwide, the number of people with cognitive deficits is expected to increase further in the future. Improving cognitive function has become one of the major challenges in medicine requiring pharmacological intervention.
As we get older, the longevity protein Klotho decreases. According to previous studies conducted with animal experiments, when this protein was injected into mice, lifespan was extended. Recent studies have shown that it improves synaptic (nerve cell junction) function in mice and improves cognitive function.
This study is the result of examining the effects of Klotho on primates with cognitive abilities similar to humans. The research team administered a single dose of 10 mg of Klotho per kg of body weight to 18 rhesus macaques with an average age of 22 years.
As a result, only one administration improved cognitive function in aged primates. When a test was conducted to evaluate working memory (the ability to temporarily store information) and spatial memory (the ability to remember a location), it was confirmed that the memory maintained an improved state for two weeks. However, high-dose Klotho administration did not show any improvement in cognitive ability.
The research team said, “The significance of this study is that it confirmed that Klotho has a positive effect not only on lab mice but also on monkeys similar to humans.” It is evaluated that this will help find a method of medical intervention to respond to the deterioration of human cognitive ability in the future.
2023-07-04 05:15:18
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