Lutfi Fauziah
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A woman is standing in front of the refrigerator.
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Nationalgeographic.co.id—Sport regularly has been proven to be beneficial for our body. At least in protecting us from obesity.
However, scientists remain curious and continue to examine more closely why regular exercise can prevent obesity at the molecular level. In a new study, scientists placed rat-rats on intense treadmill exercise and analyzing how the chemicals in the animals’ cells then began to change over time.
They found the appearance of a metabolite called Lac-Phe (N-lactoyl-phenylalanine). This metabolite is synthesized from lactate and phenylalanine.
Phenylalanine is an amino acid that combines to make protein. The lactic acid is produced by the body after strenuous exercise.
The researchers in the new study think they have discovered an important biological pathway unlocked by exercise. These open pathways then have an impact on other parts of the body, especially in the level of appetite and the amount of food consumed.
Further tests confirmed these results. The researchers gave high doses of Lac-Phe to mice on a high-fat diet, so the mice ate about half as much over the next 12 hours as a group of control mice. Meanwhile, the movement and energy expenditure of the rodents remained unchanged.
Over a 10-day period, the Lac-Phe dose led to decreased food intake, weight loss, and increased glucose tolerance in the mice. That is a positive result because today many people are thinking about ways to combat obesity and obesity-related diseases.
However, there are still some caveats that we should pay attention to regarding the use of this dosage of Lac-Phe. The difference in appetite suppression induced by Lac-Phe was only seen after exercise and in rats on a high-fat diet. The same effect was not seen in the more sedentary rats.
Also Read: Why Do We Feel Dizzy When We Are Hungry? This is the explanation
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