Studies have shown that people with vitamin D deficiency have higher body mass index, waist-to-hip ratio, fat mass index, blood pressure, glucose, insulin, triglycerides and liver marker levels than those with normal vitamin D.
After adjusting for gender, vitamin D levels were negatively correlated with body mass index, fat mass index, systolic blood pressure, and glucose metabolism-related indicators.
Glucose metabolism-related indicators here include blood glucose and insulin concentrations, insulin/glucose level ratio, and homeostasis model assessment of insulin resistance index.
Vitamin D (Sound of Hope Synthetic)
In addition, similar trends were observed for liver markers (serum gamma-glutamyl transferase and alkaline phosphatase) and the anti-inflammatory marker interleukin-4.
The researchers believe these findings support that 25-hydroxyvitamin D levels may be a useful marker of cardiovascular disease, which can be easily monitored in younger people.
This study included 177 healthy young people aged 18 to 25 in the ACTIBATE trial, all of whom had sedentary habits. 65% were female. All were non-smokers and had no history of cardiovascular disease or chronic disease.
25-hydroxyvitamin D was measured using chemiluminescence immunoassay, in which 25-hydroxyvitamin D< 20 ng/mL定義為維生素D缺乏，21-29 ng/mL定義為維生素D不足，> 30 ng/mL is the normal level. Among them, 44 participants were vitamin D deficient and 41 had normal vitamin D levels.
Previous studies have shown that spending more time in the sun can help enhance insulin sensitivity and reduce triglyceride levels, and other studies have shown that vitamin D supplementation can help improve left ventricular function.
來源：Amaro-Gahete FJ, Vázquez-Lorente H, Jurado-Fasoli L, et al. Low vitamin D levels are linked with increased cardiovascular disease risk in young adults: a sub-study and secondary analyses from the ACTIBATE randomized controlled trial. J Endocrinol Invest. 2024 Jan 4.
2024-02-19 10:28:50
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