Korean researchers “suggest the possibility of treating vascular diseases”… Identification of vascular cell pore regulation phenomenon
photo">Professor Seo Dae-ha (left) DGIST’s research team.[DGIST 제공]
[헤럴드경제=구본혁 기자] Daegu Gyeongbuk Institute of Science and Technology (DGIST) announced on the 7th that Professor Seo Dae-ha’s team in the Department of Chemical Physics discovered a mechanism that can analyze the formation and pattern formation of pore structures through which material transport occurs in capillary cells. Through joint research with Professor Lee Jun-yeop’s team at the Department of Ophthalmology at Asan Medical Center in Seoul, the research team discovered the spatial self-organization mechanism of PLVAP protein, a type of vascular cell membrane protein, and through this, was able to present a new perspective on understanding vascular diseases.
PLVAP protein is a protein that forms fenestration in endovascular cells and plays an important role in the permeability of substances in blood vessels, so it is closely related to various vascular diseases as well as cancer and central nervous system diseases. Since it is a target for various diseases, it is being studied in various fields, but the identification of molecular biological mechanisms, such as the formation process of PLVAP protein and fenestration and analysis of ultrafine structure, is still in the early stages.
Professor Seo Dae-ha’s team uncovered the activity and window formation mechanism of PLVAP protein by using single molecule tracking optical microscope imaging technology, machine learning analysis technology of image data, and ‘reaction-diffusion model’ to interpret the analysis content.
Professor Seo Dae-ha’s team found that the PLVAP protein is in a chemical equilibrium of disordered diffusion and protein-protein interaction, such as ‘Brownian motion’, but cells form a very regular fluency by controlling their reaction speed using the surrounding environment. Confirmed.
In this study, Professor Lee Jun-yeop’s team conducted animal experiments comparing normal mice and PLVAP protein mutant mice to determine how loss of vascular cell fluency and regularity, and functional decline in material transport through blood vessels are related to the onset of disease. conducted research.
As a result, we were able to uncover the physical and chemical mechanisms that control cell form and function from a new perspective that could not be understood using traditional medical and biological methods.
Professor Seo Dae-ha said, “We were able to understand new mechanisms of biological phenomena related to PLVAP protein through methodologies from various disciplines such as nanoparticle synthesis chemistry, high-resolution microscopy technology, and machine learning technology.” He added, “The results of this study provide a new way to treat vascular diseases in the future.” “We expect it to provide direction,” he said.
The results of this research were published online in January in the international academic journal ‘Nano Letters.’
nbgkoo@heraldcorp.com
COPYRIGHT ⓒ HERALD CORPORATION. All Rights Reserved.
2024-02-07 01:11:02
#Korean #researchers #suggest #possibility #treating #vascular #diseases #Identification #vascular #cell #pore #regulation #phenomenon
