▲ (From left) Professor Hyung-gon Moon and Researcher Woo-haeng Hoh of the Department of Breast Endocrine Surgery at Seoul National University Hospital. ⓒSeoul National University Hospital
Recently, the results of a study that identified a new mechanism of the process of ‘breast cancer liver metastasis’, in which breast cancer metastasizes to the liver, have been published.
Seoul National University Hospital Breast Center Professor Moon Hyung-gon’s team (Researcher Huh Woo-haeng) transplanted cancer tissues from Korean breast cancer patients into immune-suppressed mice to develop a tumor-derived xenograft model (PDX model) and investigate the mechanism of breast cancer metastasis to the liver. The results were published on the 9th.
The key point is that ‘CX3CL1’ plays an important role in the liver metastasis process of breast cancer. The extracellular vesicles secreted by breast cancer cells into the blood interact with immune cells to identify the process of creating an environment in which cancer cells can grow well in liver tissue even before cancer cells reach them.
In recognition of this research achievement, it was selected and published as a highlight paper in the July issue of Molecular cancer research, an international journal.
The research team used a xenograft model derived from triple-negative breast cancer patients with different metastases and metastatic organs to investigate the formation process of ‘nish before metastasis’ in the liver.
Pre-metastatic niche refers to the preparation of a specific organ to accept cancer cells before cancer cells reach a distant organ.
In the liver microenvironment where metastasis occurred, the CX3CR1 gene was increased, which was significantly higher in tissues of breast cancer patients with liver metastasis compared to lung metastasis.
This suggests that CX3CR1 is increased in liver tissue with breast cancer metastasis, and the increased level is a gene regulation specific to liver metastasis of breast cancer.
Dr. Woo-Haeng Huh (Researcher at the Korea Biomedical Research Institute) said, “Measurement of the concentration of CX3CL1 protein in the blood of breast cancer patients can predict high-risk patients who may develop liver metastases in the future, so it can be an alternative to targeted treatment strategies.” said.
Professor Moon Hyung-gon (Breast Endocrine Surgery) said, “Until now, in breast cancer, it has not been known what role this ‘pre-metastatic nish’ plays in liver metastasis.
2023-08-09 01:14:00
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