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Understanding patterns of fatigue in health and disease: protocol for …Introduction. Fatigue is a major clinical problem and is prevalent in most chronic medical conditions. Problematic fatigue is experienced by up to 98% of individuals with myeloma,1 around 50% of those with heart failure2 and over 70% of those with long COVID.3 Fatigue is a multifaceted, fluctuating symptom which embodies biological, biochemical, physiological, psychological, emotional and …
PDF patients report fatigue as an adverse drug reaction of biologics – Lareb Pattern of recurring fatigue after each biologic management: 48% Recovery within one week: 88% (42 out of 48 patients) … 2.9 ±0.9 2.4 ±1.1 <0.001 Patients with fatigue: Younger Smoked more often Used infliximab, rituximab or vedolizumab more often ...1. Pharmacovigilance centre Lareb, 's-Hertogenbosch, NL 2. Erasmus Medical Centre ...
Biological mechanisms of chronic fatigue – Oxford Academic Chronic fatigue is a common, poorly understood and disabling phenomenon in many diseases. We aim to provide an overview of fatigue in chronic autoimmune and inflammatory disease. Fatigue measurement, prevalence and confounding factors such as depression, sleep disorders and pain are reviewed in t…e people indicated that they are tired after every injection of these medicines. That is why we have now further investigated fatigue around injection.
Research In this study we looked at the patterns in the course of fatigue around the injection of these drugs in people with inflammatory rheumatism who use a biological medicine. Participants gave a figure about their fatigue of that day around three injections for five days. 609 people participated in this study that was conducted together with the Sint Maartens clinic.
The results We investigated how many people got worse,got better or remained right after an injection. If this course for one person was the same for most injections, we called it a pattern. A total of 398 people filled in enough figures to investigate patterns. For most people (61%), fatigue remained the same after the injections. But in 13% fatigue got worse after the injections and 18% always felt less tired after the injection.
Look here for the infographic about the results of the survey.
Bron: Lareb
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Interview with Dr. Jane Doe: Understanding patterns of Fatigue in Health and Disease
Fatigue is a notable clinical concern affecting numerous individuals with chronic medical conditions. In this interview, we sit down with Dr. Jane Doe to discuss her latest research on the patterns of fatigue and its implications for health and disease.
Editor: Why is fatigue such a pervasive issue among patients with chronic conditions?
Dr. Jane Doe: Fatigue is a multifaceted symptom that can befluence by biological, biochemical, physiological, psychological, emotional, and social factors. As an example,individuals with multiple myeloma,heart failure,and long COVID report fatigue rates of up to 98%,50%,and over 70%,respectively. This highlights the need for a comprehensive understanding of fatigue patterns to develop effective management strategies.
Editor: Can you elaborate on the biological and biochemical factors contributing to fatigue?
Dr. Jane Doe: Certainly. Biological factors include hormonal imbalances, inflammation, and changes in neuromuscular function. Biochemical factors involve metabolic disturbances and oxidative stress. These factors often interplay, creating a complex environment that exacerbates fatigue in chronic conditions.
Editor: What do you make of the recent findings from the Lareb survey on fatigue related to biologics?
Dr. Jane Doe: The Lareb survey results are notably captivating. They show that for most individuals (61%), fatigue remained the same after biologic injections. However,for 13%,fatigue worsened,and for 18%,fatigue was alleviated. this pattern suggests variability in how people respond to biologics, underscoring the need for personalized treatment plans.
Look at the infographic for a visual representation of the survey results.
Editor: how does the psychology and emotional state of patients influence their experience of fatigue?
Dr. Jane Doe: Psychological and emotional factors play a significant role in fatigue perception.Stress, anxiety, and depression can amplify fatigue symptoms. Additionally, the emotional burden of living with a chronic condition contributes to overall fatigue levels. Addressing these psychological and emotional aspects is essential for developing holistic treatment strategies.
Editor: What advice do you have for healthcare providers managing patients with chronic fatigue?
Dr. Jane Doe: healthcare providers should adopt a multidisciplinary approach, incorporating psychological support, physical therapy, and personalized treatment plans. It’s also vital to educate patients about the multifaceted nature of fatigue and empower them to manage their symptoms proactively.
Editor: Are there any emerging therapies or interventions that show promise in managing fatigue?
Dr. Jane doe: Emerging therapies include non-pharmacological interventions like cognitive-behavioral therapy, mindfulness, and exercise routines tailored to the needs of patients.Pharmacological approaches, such as abortive agents targeting specific physiological pathways, are also being investigated. Ongoing research aims to refine these treatments for optimal outcomes.
Editor: what are the main takeaways from your research on fatigue patterns?
Dr. Jane Doe: The main takeaways are that fatigue is a complex,multifaceted symptom influenced by various biological,biochemical,psychological,and emotional factors. Understanding these interplaying elements is crucial for developing personalized treatment strategies. Our research underscores the importance of a multidisciplinary approach to fatigue management in chronic conditions.
