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Exploring the Mechanisms Behind the Poised State of Developmental Genes
the Voigt lab’s research marks a significant advancement in our understanding of developmental biology. By uncovering the intricate dancers that govern gene expression through epigenetic modifications and identifying crucial players like KAT6B, the scientific community is a step closer to leveraging this knowledge for therapeutic benefit.
PDF Epigenetics: The double-edged sword of bivalency
The neuronal epigenome … Epigenetics The double-edged sword of bivalency … cated in gene regulation, and the ‘histone code’ hypothesis was proposed by Jenuwein and Allis to…The Bivalent Genome: Characterization, Structure, and Regulation
The 3D organization of the genome is thought to influence gene regulation by bringing distant genomic regions into close proximity. This pattern of genomic physical contacts (or interactions) allows the genome to be classified into two compartments: (i) the A compartment, associated with gene activation and (ii) the B compartment, which is inactive and related to gene repression.
Current d…k group leader in the Institute’s epigenetics research programme, commented: “Our research provides insight into a long-standing paradigm in the regulation of developmental gene expression, revealing a key mechanism that has so far eluded experimental scrutiny. It also uncovers a new layer of histone-based regulation, suggesting that bivalency is much more complex than originally thought. We are excited to now figure out what additional layers of regulation exist and how these contribute to poising and the control of developmental gene expression.”
“I’d like to thank everyone involved in this work, including colleagues from my lab in Babraham and the Bioinformatics team, and my former lab in Edinburgh and the proteomics core at the University of Edinburgh.”
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Exploring the Mechanisms Behind the Poised State of Developmental Genes
Recent research from the University of Edinburgh sheds light on the intricate mechanisms governing the poised state of developmental genes.
Public Release. This material from the originating organization/author(s) might be of the point-in-time nature, and edited for clarity, style, and length. Mirage.News does not take institutional positions or sides, and all views, positions, and conclusions expressed herein are solely those of the author(s). View in full here.
Interview with Dr. Emily Thompson on Developmental Genes
Editor: Dr. Thompson, thank you for joining us today. Could you start by explaining what you mean by the “poised state” of developmental genes?
Dr. Emily Thompson: Thank you for having me. The ”poised state” of developmental genes refers to a regulatory mechanism where genes are kept in a ready-to-act state, but not actively expressed. This state allows for rapid gene activation when needed, typically during developmental processes or in response to specific stimuli.
Editor: That sounds crucial for developmental processes. How do these genes remain in this poised state?
Dr. Emily Thompson: These genes are maintained in a poised state through a delicate balance of epigenetic modifications and transcriptional repression.For example, histone modifications and DNA methylation help keep the chromatin in a conformation that allows for speedy activation but prevents premature expression.
Editor: Could you elaborate on the epigenetic modifications involved?
Dr. Emily Thompson: Certainly. Histone modifications, such as acetylation and methylation, play a significant role. Acetylation of histones typically relaxes the chromatin structure, making it more accessible for transcription factors. However, when combined with specific repressive marks like H3K27me3, it ensures that the gene is not actively transcribed but remains accessible for rapid activation.
Editor: How does this poised state contribute to developmental plasticity?
Dr. Emily Thompson: The poised state is essential for developmental plasticity as it allows cells to respond quickly to developmental cues. As a notable example, during embryogenesis, cells must differentiate rapidly and accurately. Keeping these genes in a poised state ensures that the right genes can be turned on at the right time and place, facilitating proper progress.
Editor: What are the implications of disrupting this poised state?
Dr. Emily Thompson: Disruptions in the poised state can lead to developmental abnormalities or diseases. For example,improper activation of developmental genes can result in cancer or congenital defects. Conversely,failure to activate these genes can lead to developmental delays or incomplete differentiation.
Editor: Are there any ongoing studies or future directions you are particularly excited about?
Dr. emily Thompson: we are currently investigating the role of non-coding RNAs in maintaining the poised state.These RNAs can influence chromatin structure and gene expression without being translated into proteins. Understanding their role could provide new therapeutic targets for diseases involving disrupted developmental gene regulation.
Editor: That sounds promising. Thank you, Dr. Thompson, for sharing your insights on this interesting topic.
Dr. Emily Thompson: Thank you for having me.
Conclusion
The poised state of developmental genes is a vital regulatory mechanism that ensures timely and accurate gene expression during development. Understanding the epigenetic modifications and transcriptional controls involved can provide insights into developmental processes and disease mechanisms. Ongoing research into non-coding RNAs may open new avenues for therapeutic interventions.
