Development of a new compound with the same effect as exercise… expected to help patients with neurodegenerative diseases in the future
Entered 2024.04.04 18:05 Entered 2024.04.04 18:05 Modified 2024.04.04 17:33 Views 6,226
Wouldn’t it be great if there was a way to get the benefits of exercise without exercising? In fact, it is predicted that in the future, it will be possible to achieve the same effect as exercise with just one pill. [사진=게티이미지뱅크]Exercise is the act of moving the body for health. A series of effects obtained by moving the body are important for leading a healthy life. Wouldn’t it be great if there was a way to get the benefits of exercise without exercising? In fact, it is predicted that in the future, it will be possible to achieve the same effect as exercise with just one pill. Of course, it’s not for people who don’t want to exercise or are lazy.
As a result of a rat experiment conducted by Dr. Bach Elgendy’s team in the Department of Anesthesiology at Washington University School of Medicine in St. Louis, USA, it was discovered that certain compounds can mimic the physical effects of exercise within cells. The content presented at the hybrid meeting (simultaneously held online and offline) of the ‘AMERICAN CHEMICAL SOCIETY Spring Conference’ held from March 17th to 21st shows that muscle atrophy and other diseases, including heart failure and neurodegenerative diseases, can be treated. It is anticipated that this could become a new method.
Dr. Bach Elgendy said, “Exercise is important at all levels and is an irreplaceable activity. If you can exercise, you should exercise. However, the benefits of exercise are often needed for people who cannot exercise.” .
The powerful physical effects of exercise lie in stimulating the metabolism and growth of muscle cells and improving muscle performance. “Drugs that can mimic these effects are needed when people are unable to engage in regular physical activity as they age, have cancer, certain genetic disorders, or other reasons,” the researchers said. The explanation is that this drug can offset muscle atrophy and weakness that can occur due to some diseases. This action can, for example, prevent weight loss drugs from causing the body to lose both fat and muscle.
Dr. Bach Elgendy, Department of Anesthesiology, Washington University School of Medicine in St. Louis, USA, is explaining his research online at the ‘American Chemical Society Spring Meeting’ hybrid meeting (simultaneous online and offline) held from March 17th to 21st. [사진= 미국 화학회 춘계학술대회’ 유튜브 영상 캡처]Study of compound SLU-PP-332, which targets estrogen-related receptor (ERR)… A new upgraded compound was developed and simulation results show that the exercise effect is stronger.
Exercise-related metabolic changes in the body begin with the activation of special proteins known as estrogen-related receptors (ERRs), which exist in three forms. This type of ERR regulates exercise-induced stress adaptation and other important physiological processes in muscles. After about 10 years of research, Dr. Elgendy’s team developed a compound called SLU-PP-332, which activates all three forms (ERRα, ERRβ, and ERRγ), including ERRα, the most difficult target of this receptor.
In experiments on rats, the team found that the compound increased fatigue-resistant types of muscle fibers while also improving endurance when running on a treadmill.
To further confirm the effectiveness of SLU-PP-332, the researchers closely examined the structure of ERR and its binding method with the molecule that activates it. They then designed a new molecule that could enhance the interaction with the receptor and trigger a stronger response than SLU-PP-332. The molecule was optimized by considering other properties such as stability and minimizing the possibility of toxicity. Molecular modifications were also made to enable patenting.
Afterwards, RNA, a measure of gene expression, was examined in about 15,000 genes in mouse heart muscle cells, and the efficacy of SLU-PP-332 was compared with that of the new compound. The new compound increased the presence of RNA to a greater extent, suggesting it could more powerfully simulate the effects of exercise.
Research using SLU-PP-332 suggests that targeting ERR may be useful in certain diseases. Animal experiments using it showed that it could prevent obesity, heart failure, or decline in kidney function due to aging. This suggests that new compounds may have similar effects.
The activation of the aforementioned estrogen-related receptor ERR is known to respond to damaging processes that occur in the brains of patients with Alzheimer’s disease and other neurodegenerative diseases. SLU-PP-332, which the researchers previously developed, was not delivered to the brain, but some of the new compounds were developed to be delivered to the brain.
“ERR plays an important role in all diseases,” said Dr. Elgendy. “If there were a compound that could effectively activate it, it could create many beneficial effects related to exercise.”
The researchers plan to test the new compound in animal models through Pelagos Pharmaceuticals, a startup company they co-founded. The possibility of developing this compound as a potential treatment for neurodegenerative diseases is also being considered. The study was conducted with support from the National Institute on Aging, part of the National Institutes of Health.
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2024-04-05 11:18:35
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