Researchers from the Mayo Clinic in Rochester, Minnesota, have developed a new chronic wound murine model to investigate skin cellular senescence. The model explores the link between cellular senescence and delayed wound healing. Senescence, the essentially irreversible cell cycle state resulting from damaging stimuli, has been found to be beneficial in the acute wound healing phase but harmful in chronic wounds. This study presents a novel oxidative stress-induced chronic murine wound mouse model in which there is capacity to target aberrant senescent cell expression. The researchers concluded that this study is the first chronic wound murine model to profile the effects of chronic cellular senescence linked to delayed wound healing and could have significant implications for developing interventions that target cellular senescence for chronic or stalled wounds as a root cause-driven therapeutic strategy. The research paper was published on the cover of Aging. More information can be found in the paper published in Aging.
