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15 Dec. 2023 09:20 a.m.
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Tuberculosis is a widespread infectious disease. It affects millions of people each year. Previously it was the leading cause of death. This disease is caused by bacteria. Mycobacterium tuberculosis which detects tuberculosis early This is considered a challenge because Mycobac terium tuberculosis can hide in macrophages, a type of white blood cell that is responsible for eating foreign substances that have slipped into the human body. Although tuberculosis can be treated with common antibiotics, But repeated exposure of bacteria to these drugs May result in bacteria becoming resistant to multiple drugs.
But the researchers did not give up and found a way to fight. A few years ago A research team led by experts from the Dresden University of Technology in Germany has developed a natural substance called Polyprenylated polycyclic acylphloroglucinols (PPAP), a derivative of PPAP53, is characterized by high potency and promising promise in combating multidrug-resistant tuberculosis. and opens up new perspectives in treating diseases caused by degenerative nervous system disease.
The team determined that by studying a specific substance, PPAP or PPAP53, it can stimulate human macrophages to fight drug-resistant TB bacteria without being toxic. The fight against tuberculosis within macrophages is achieved in the early stages of infection. and avoid the onset of resistance before symptoms of infection appear. Multiple tests suggest that PPAP53 specifically fights intracellular tuberculosis. By passing or stimulating cell membranes without destroying macrophages. This is another advantage of PPAP53 over existing drugs. That is, it does not increase the concentration of liver enzymes.
(Credit : Journal of Medicinal Chemistry (2023). DOI: 10.1021/acs.jmedchem.3c01172)
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2023-12-15 02:20:00
#compound #fights #tuberculosis
