Nature Medicine: Breakthrough infection, significantly reduces infectivity of Omicron

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Author | Yi Nuowei Source | Yi Nuowei (ID: inovelt)

coronavirus, usually infect humans through the respiratory tract and cause damage to the respiratory system and various organs in the human body. Since the first outbreak in late 2019, the new coronavirus is still raging around the world, causing a large negative impact on the global economy and society.

With the large-scale epidemic of the novel coronavirus, new mutant viruses continue to emerge, such as Alpha, Beta, Gamma, Delta, Omicron, etc., some of which have higher infection capacity or higher immune escape capacity.

January 2, 2023, United StatesUniversity of Californiaresearchers in ” Medicine of Nature A research paper titled “Infectiousness of Breakthrough Infections and Reinfections of SARS-CoV-2 During the Omicron Wave” was published in the journal.

The study proved itImmunity from vaccines and infections can reduce Omicron contagionsex. Vaccination with any vaccine reduces the risk of contagion by 22 percent; early infection reduces the risk of contagion by 23 percent; vaccination and previous infection reduce the risk of contagion by 40 percent. Booster vaccination can further reduce the risk of infection。

In the study, researchers analyzed transmission between people living in the same cell, including 111,687 participants between December 15, 2021 and May 20, 2022, whose primary vaccination rate reached 81%, 22,334 Omicron infections, 31 hospitalizations and no deaths. registered in a period longer than 5 months.

The study found,Vaccinated participants were significantly less infectious after a breakthrough infection than unvaccinated individuals(36%)the risk of contagion is reduced to 28%. But over time, the risk of contagion has increased by 6% for every five weeks that have passed.

Natural immunity is also protective in people who have been infected before, with a 23% risk of spreading the virus in people who have been reinfectedwhile the risk of transmitting the virus from those who have never been infected is 33%.

For both vaccinated and infected people, the risk of spreading the virus is further reduced by 40%. This protection is due half to the vaccine and half to immunity acquired after infection.

Contagion rates vaccines, infected, vaccinated and infected

also,Booster shots also reduce infectivity, with each additional dose reducing the likelihood of transmission by 11%。

The study also found thatPeople are less contagious in the two months following vaccinationsuggesting that booster immunization and timed mass vaccination may help reduce transmission.

In conclusion, the research suggests that being vaccinated, or already infected, provides additional protection and reduces the risk of further infection, highlighting the importance of booster shots and timed vaccinations to reduce transmission.

Not only that, on May 18, 2022, the United StatesUC Gladstone Instituteresearchers in ” Nature The journal published a research paper titled “SARS-CoV-2 Omicron Limited Cross-Variant Immunity Without Vaccination.”

research shows,Omicron’s breakthrough infection boosts vaccine-triggered immunity in vaccinated peoplein unvaccinated populations, Omicron infection induces a humoral immune response against Omicron variants but does not confer broad protection against other variants.

Paper link:

https://doi.org/10.1038/s41591-022-02138-x

https://doi.org/10.1038/s41586-022-04865-0

Editor’s note: This article is reproduced from WeChat public account: Yi Nuowei (ID: inovelt), author: Yi Nuowei