Natural cardamom compound may have therapeutic effect on triple negative breast cancer

Paris, April 4 (Benin News) –

Cardamom, a natural compound found in cardamom and other plants, may have triple anticancer therapeutic potential, according to a study of human cancer cells by researchers at the University of Florida.

About 10 to 15% of breast cancers are triple negative, meaning they don’t have estrogen or progesterone receptors and don’t produce high levels of a protein called HER2. These tumors are difficult to treat because they do not respond to hormone treatments used for other types of breast cancer. They are more serious and have a higher death rate than other breast cancers.

“Developing a targeted treatment for trinegative breast cancer is safe and effective. For this reason, it is absolutely essential to study medicinal plants as a new way to fight this cancer”, say experts at the annual meeting of the American Society for Investigative Pathology as part of Experimental Biology (BE). The 2022 meeting will take place April 2-5 in Philadelphia.

For this new study, the researchers looked at how cardamom influenced the expression of the PD-L1 (programmed cell death ligand 1) gene in tumor cells. PD-L1 is highly stressed during the development of breast cancer and plays an important role in helping cancer cells prevent the body’s immune system.

The researchers used two genetically distinct negative breast cancer cell lines: one for African-American women and the other for European (Caucasian) women. They found that cardamom treatment caused a dose-dependent decrease in cell viability in both cell lines.

Furthermore, it reduced PD-L1 expression in the Caucasian cell lineage, but not in the African-American cell lineage, indicating that different cell species may respond differently to cardamomine due to interspecies genetic variation.

“This is the first study to describe the inhibitory effect of cardamom on PD-L1 exposure, which is relevant to the treatment of three negative breast cancers.

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