Modulation of the innate immune response by African swine fever virus

Abstract : African swine fever (ASF) is a highly pathogenic disease causing haemorrhagic fever in domestic and feral pigs. It is responsible for numerous animal diseases, particularly in Europe and Asia, causing serious economic losses for the pig industry. African swine fever virus (ASFV) is the causative agent responsible for this disease. It is a very large double-stranded DNA virus, encoding over 150 proteins. Various studies have shown that there is a close relationship between the ability of some viral proteins to inhibit the response to type I interferon (IFNI) and the attenuation and virulence processes of ASFV. This review describes the mechanisms of inhibition of the IFN-I response by ASFV proteins, which provide a molecular explanation of how ASFV evades the innate immune response.

Take up again : African swine fever (ASF) is a highly pathogenic disease causing haemorrhagic fever in domestic and wild pigs. It is responsible for many epizootics, particularly in Europe and Asia, causing huge economic losses for the pig industry. African swine fever virus (ASF) is the causative agent responsible for this disease. It is a virus with a large double-stranded DNA genome, coding for more than 150 proteins. Various studies have shown that there is a close relationship between the ability of some viral proteins to inhibit the response to type I interferon (IFN-I) and the attenuation and virulence processes for PSA. This review describes the mechanisms of IFN-I response inhibition by ASFV proteins that provide a molecular explanation for the escape of the innate immune response.