▲ Research results have shown that migraines and breast cancer may be genetically linked. (Photo = DB)
[메디컬투데이=최재백 기자] Research has shown that migraines and breast cancer are genetically linked.
Research results showing that migraines and breast cancer may be genetically linked were published in ‘BMC Cancer.’
A research team at the Cancer Center of West China Hospital, Sichuan University, China, focused on the genetic link between migraine and breast cancer.
Migraines and breast cancer are both accompanied by changes in estrogen levels, and high estrogen levels can increase the risk of developing breast cancer. Additionally, the severity and frequency of migraines in women may be affected by changes in estrogen levels due to the menstrual cycle, menopause, or pregnancy.
Accordingly, research on the relationship between migraine and breast cancer has been conducted in the past, but the results are inconsistent, diverse, and sometimes contradictory, and have not been clearly revealed.
The Chinese research team collected genetic data from migraine patients and breast cancer patients from genome-wide association analysis (GWAS). Migraine-related genetic information was collected from more than 102,000 migraine patients and 771,000 control subjects, and breast cancer-related genetic information used data from the Breast Cancer Association Consortium (BCAC).
As a result of investigating the causal relationship between migraine and breast cancer using Mendelian randomization, it was found that women with migraine had a high risk of developing overall breast cancer and estrogen receptor (ER)-positive breast cancer.
Additionally, the research team added that female patients with migraine without aura had a higher incidence of ER-negative breast cancer and overall breast cancer.
Experts assessed that it is difficult to prove a link between migraine, which is a non-specific and common disease, and breast cancer, and that a conclusion can only be drawn if the same trend is confirmed in other countries or population groups.
Medical Today Reporter Jaebaek Choi (jaebaekchoi@naver.com)
[저작권자ⓒ 메디컬투데이. 무단전재-재배포 금지]
2023-10-04 02:09:46
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