The study of the transgenerational (developed by Salomón Sellam) is one of the fundamental parts of biodecoding and one of the newest concepts. It proposes that the conflictive situations experienced by the ancestors leave an emotional imprint on the clan’s subconscious, which can be perceived with greater intensity by some of its members, strongly marking part of their emotional programming.
The study that we present supports this hypothesis by showing that the traumatic experiences of parents can be transmitted to their children and even grandchildren through the seminal cells.
Animal studies suggest that behavior may be affected by events in previous generations, which have been passed down through a form of genetic memory.
The experiments showed that a traumatic event can affect sperm DNA and alter the brain and behavior of subsequent generations.
Furthermore, a study in the journal Nature Neuroscience shows that mice trained to avoid an odor passed their aversion to their “grandchildren.” The experts said the results were important for research on phobia and anxiety.
Brian G. Dias and Kerry J. Ressler from the Emory University School of Medicine team in the USA trained the animals to fear a cherry blossom-like smell and then observed what was happening inside. of sperm. They showed that a section of DNA, responsible for cherry blossom scent sensitivity, became more active in the sperm of the mice. Both the offspring of the mice, and their “grandchildren”, were “extremely sensitive” to cherry blossoms and avoided the smell, despite never having experienced it in their lives. Changes were also found in the structure of the brain.
“The experiences of one parent, even before conception, markedly influence both the structure and function of the nervous system of later generations,” the report concluded.
Family matters
The results provide evidence for “transgenerational epigenetic inheritance” – that the environment can affect an individual’s genetics, which in turn can be passed on.
One of the researchers Dr. Brian Dias told the BBC: “This could be one of the mechanisms by which the descendants show traces of their ancestor.” There is absolutely no doubt that what happens to the sperm and egg will affect later generations. “
Prof. Marcus Pembrey, University College London, said the results were “highly relevant to phobia, anxiety and post-traumatic stress disorders”, and provide “compelling evidence” that a form of memory could be passed from one generation to the next.
He commented: “It is time for public health researchers to take human transgenerational responses seriously.” “I suspect that we are not going to understand the increase in neuropsychiatric disorders or obesity, diabetes, and metabolic disorders generally without taking a multigenerational approach.” In the study of odor aversion, it is believed that either some of the odor ends up in the bloodstream that affects sperm production or that a signal from the brain was sent to the sperm to alter the DNA.
All these investigations prove that the olfactory experience of the parents influences the behavior and neural structure in later generations.
In another study, using olfactory molecular specificity, the inheritance of traumatic exposure from parents was analyzed, a phenomenon that has been frequently observed but not understood. We subjected F0 mice to conditioning for fear of an odor before conception and found that the subsequently conceived F1 and F2 generations had increased behavioral sensitivity to conditioned odor, but not to other odors.
When an odor (acetophenone) that activates a known odorant receptor (Olfr151) was used to condition the F0 mice, the behavioral sensitivity of the F1 and F2 generations to acetophenone was complemented by an improved neuroanatomical representation of the Olfr151 pathway. Bisulfite DNA sequencing of sperm from F0 conditioned males and unconditioned F1 offspring revealed CpG hypomethylation in the Olfr151 gene. Additionally, in vitro fertilization, F2 inheritance, and cross-adoption revealed that these transgenerational effects are inherited. through parental gametes Our results provide a framework to address how environmental information can be inherited transgenerationally at the behavioral, neuroanatomical, and epigenetic levels.
Fuentes: BBC News / Nature / libertademocional.es
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