Pancreatic islet function is the “manufacturer” of insulin
Whether blood sugar is good or not, pancreatic islet function is the most critical.
In the fasting state in the morning, before and after eating 75 grams of glucose or 100 grams of flour steamed buns, venous blood was drawn on an empty stomach, half an hour after the meal, 1 hour after the meal, 2 hours after the meal, and 3 hours after the meal.
Measure blood sugar, insulin concentration or C-peptide value at 5 time points respectively, and let the doctor evaluate your current pancreatic islet function.
Islet (Public domain)
The British Prospective Diabetes Study found that when patients with type 2 diabetes develop, pancreatic islet function has been reduced by 50%.
As the course of diabetes prolongs, the insulin-secreting function of pancreatic islet B cells decreases at a rate of 2% per year. In severe cases, the function of insulin secretion is even completely lost, which means that the patient must rely on insulin treatment.
Only by maximizing the protection of pancreatic islet function can blood sugar be controlled to target with less or even no use of drugs or insulin.
01
Control high blood sugar as soon as possible
It is recommended to adopt a multi-pronged approach of diet, exercise, medication, and monitoring to keep blood sugar stable. Only by controlling high blood sugar as soon as possible and maintaining long-term blood sugar stability can high blood sugar be prevented from harming the pancreatic islets.
The longer hyperglycemia lasts, the greater the damage to pancreatic islet function.
Once monitoring detects high blood sugar, be sure to find out the cause, seek help from a doctor if necessary, and take correct treatment measures.
Measure blood sugar (pixabay)
02
Arrange your diet properly
A reasonable diet, controlling total energy intake, and not overeating can help diabetic patients control blood sugar, reduce the burden on pancreatic islet B, and promote the recovery of pancreatic islet function.
Avoid excessive drinking and preferably abstain from alcohol. Excessive drinking can cause oxidative damage to pancreatic islets, causing pancreatic islet B cell apoptosis, leading to impairment of pancreatic islet function.
Stick to a low-fat diet. If there is too much fat intake in the diet, free fatty acids produced during lipid metabolism will increase. If too many free fatty acids are stored in pancreatic islet B cells, it will affect the ability of pancreatic islet B cells to secrete insulin and damage islet B cell function.
Patients with mild diabetes can effectively control blood sugar through dietary therapy.
03
Keep weight within normal range
Weight gain will increase the burden on pancreatic islet B cells. Losing weight and maintaining a reasonable weight, not being too fat or too thin, can also reduce the damage of lipotoxicity to pancreatic islet B cells and protect the function of pancreatic islet B cells.
The simplest way to measure whether your weight is up to standard is your waist circumference: a waist circumference of less than 90 centimeters for men and less than 85 centimeters for women.
04
Use certain blood sugar-lowering drugs under the guidance of a doctor
Such as GLP-1 receptor agonist drugs, which are drugs with the word “peptide” in the drug name. GLP-1 acts on pancreatic islet B cells, promoting insulin gene transcription, insulin synthesis and secretion, stimulating islet B cell proliferation and differentiation, inhibiting pancreatic islet B cell apoptosis, etc., and playing a role in protecting pancreatic islet function.
Another example is Siglitar Sodium, the world’s first PPAR agonist drug for the treatment of type 2 diabetes. It can improve the insulin resistance of tissue cells, increase the utilization rate of insulin, and reduce the secretory burden of pancreatic islet cells.
Diabetic patients must use hypoglycemic drugs rationally under the guidance of a doctor.
05
Keep exercising to improve insulin resistance
After exercise, the permeability of muscle cell membranes to glucose will increase, which is like opening a back door in the cells, allowing more blood sugar to directly enter the muscle cells for metabolism. At the same time, exercise can improve insulin resistance. Jogging, Tai Chi, brisk walking, etc. are recommended.
2024-03-29 09:46:27
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