The 34-year-old Frenchman will face this Friday Taylor Fritz, seeded number 1 and as such the favorite of the event, who eliminated the Ecuadorian Emilio Gomez.
Mannarino, who remains on a quarter-final loss last week in Dallas, was very solid, managing to never give up his service game, while converting three of the seven break points he created.
He was also rewarded for his aggressiveness in the rally, resulting in 23 winners against 11, including nine aces.