This study conducted a two-part analysis on more than 650,000 people. The first was a Swedish adult cohort with a sample size of 53,416, 28,123 peripheral arterial disease patients and 128,459 controls in the Million Veterans Project, and the UK Biobank Study The relationship between sleep and peripheral arterial disease was analyzed in 452,028 participants; afterward, the causal analysis was further carried out in 31,307 cases of peripheral arterial disease and 211,753 controls using double-sample Mendelian randomization.
A study conducted in a cohort of Swedish adults showed that compared with those who slept 7-8 hours per night, those who slept too short (<5 h) or too long (≥8 h) had a 74% and 24% increase in sleep duration, respectively. Risk of peripheral arterial disease. People with peripheral arterial disease (PAD) suffer from insufficient blood flow to the upper and lower extremities (commonly seen in the lower extremities) to meet the body's needs. This may cause symptoms such as leg pain when walking (limping).
Similar results were confirmed in analyzes of two cohorts from the Million Veterans Project and the UK Biobank.
The study also found that daytime napping also increased the risk of peripheral artery disease by 32 percent.
Mendelian analysis supports an increased risk of peripheral arterial disease with nightly short sleep, but fails to establish a causal relationship between excessive sleep duration and afternoon naps and peripheral arterial disease.
The researchers said that this study shows that sleeping 7 to 8 hours per night is a good habit to reduce the risk of peripheral artery disease, and more research is needed to analyze the relationship between excessive nighttime sleep time, daytime naps and peripheral artery disease. Relationship.
