Know 3 technologies used to produce the COVID 19 vaccine
February 24, 2021 at 10:07 a.m.
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Medical experts explain three key technologies used in the production of the COVID 19 vaccine. Point is safe Revealed people who have already been infected can be vaccinated. To have adequate immunity
Prof. Dr. Viporn Wiprakasit, Department of Pediatrics Specialist in molecular medicine, Faculty of Medicine Siriraj Hospital Mahidol University And the 2021 National Distinguished Researcher says there is now a large amount of real and false information about the COVID 19 vaccine in the media. Causing confusion in society Therefore, we would like to understand as follows
This is because COVID-19 uses “S protein” to bind to human cells to insert itself into growth in the human body. The vaccination method is used. “Thorns” is the protein used to stimulate the immune cells to recognize and remember. When found the real virus Immune cells destroy the virus that can enter. Prevent infection or if the infection has mild symptoms
Currently, there are three major production technologies of the COVID 19 vaccine:
1.mRNA technology To vaccinate the RNA genetic material that makes the virus S protein But usually the virus genetic material has a shell. Without a shell it is unstable and cannot stimulate immunity. Therefore enveloping the fat at the nano level But the storage of this kind of vaccine requires a very low temperature of minus 80 degrees Celsius, which is a hot country in Thailand. High temperature The storage is challenging. Improper storage will affect efficiency and safety. Pfizer and Modenar use this technology in their production.
2. Viral Vector Technology It is the invention of DNA genetic material to make the S proteins of the coronavirus. And covered with a shell from another virus to be introduced into the body Using the genetic material virus shell, it can be stored at a temperature of about 4 degrees Celsius. Therefore suitable for Thailand with hot weather This technology has companies Russian Astrazeneca and Sputnik used in vaccine production
3. Lethal infection technology Can be achieved by bringing the virus really Come to cultivate more numbers And put some substance to the dead No more pathogenic properties Then used to make a vaccine by adding immune stimulants The technology has long been used for rabies, polio and hepatitis vaccines for vaccine production with this technology from Sinovac and Sinofarm companies from China.
Prof. Dr. Vipra continued that The development of the vaccine Safety is the number one priority. With research at both the laboratory animal level Is in mice and monkeys Three stages of human research to look at safety and efficacy. If passed by the World Health Organization criteria, it will be registered for use. Many countries around the world, including Thailand, approve it for use in emergencies. By confirming that people who have already been infected can be vaccinated To have adequate immunity Pain, swelling, fever after vaccination can occur with any vaccine. And confirm that with the current information The use of vaccines with RNA and DNA had no effect on any alteration of the human genetic code.
“The COVID-19 vaccination fits into the context of our country. And is going to start operations this week It is an important measure. To help make the people of Thailand and our country Go through this crisis. “Prof. Dr. Vipra said.
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