The drug that promises to revolutionize the treatment of obesity is currently in clinical trials. The pill works in such a way that those who want to lose weight do not have to follow restrictive diets.
A drug that promises to revolutionize the treatment of obesity is being studied in South Korea: it works at the brain level, without the need to follow restrictive diets.
We will be able to eat whatever we want without worrying about getting fat. A dream for many, which one day could become reality thanks to a new drug called KDS2010. Currently only in clinical trials, the wonder drug could represent a breakthrough in the treatment of obesity, a condition that affects over a billion people worldwide.
Developed by a team of researchers led by C. Justin LEE, director of the Center for Cognition and Sociality (CCS) at the Institute for Basic Sciences (IBS) in Daejeon (South Korea), KDS2010 showed surprising results in animal tests, reveals a study published in the journal Nature. “We look at KDS2010 as a potential next-generation obesity treatment that can effectively combat obesity without suppressing appetite,” explains LEE, according to AFP.
Astrocytes are the stake
What is the secret of this revolutionary medicine “made in Korea”? The core of the discovery lies in astrocytes, the brain’s non-neuronal stellate cells, which have been shown to play a crucial role in regulating fat metabolism.
Astrocytes interact with a specific group of neurons, known as GABRA5 clusters. These neurons are, in turn, connected to brown adipose tissue, which is responsible for heat production and therefore energy consumption.
In a diet-induced obese mouse model, the researchers observed a significant slowing of the activity of these neurons. And when GABRA5 activity was inhibited, there was a reduction in heat production in brown adipose tissue, leading to fat accumulation and weight gain.
Astrocytes in the brain begin to produce an enzyme called MAO-B (Monoamine Oxidase B), which plays a crucial role in neurotransmitter metabolism and produces large amounts of GABA, which in turn inhibits GABRA5 neurons.
By suppressing the MAO-B gene in astrocytes, the researchers were able to reverse this inhibition, allowing for greater heat production in brown adipose tissue and thus weight loss.
Diet pill that does not affect appetite
The anti-obesity drug KDS2010 acts as an inhibitor (selective and reversible) of MAO-B. In tests on obese mice, the drug demonstrated a substantial reduction in fat accumulation and weight, without any impact on the amount of food ingested. This confirms that the MAO-B enzyme in astrocytes can be an effective target for treating obesity without affecting appetite.
The discovery of the role of astrocytes and GABRA5 in the brain represents a significant advance in the understanding and treatment of obesity. “Previous treatments for obesity have mainly focused on neural mechanisms related to appetite regulation,” one researcher points out.
“Now, with the introduction of KDS2010, we have a new and promising avenue to explore in the treatment of this global disease.” Although the drug is still in the experimental phase and therefore will take some time to reach the market, researchers are optimistic that with the advent of KDS2010, the future of obesity treatment could be much easier, giving hope to millions of people suffering from obesity. This one.
Even if some doubts arise. One of them would be the health implications of a treatment that allows us to lose weight without food restrictions, regardless of our general state of health.
2023-09-12 17:27:10
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