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A joint research team of Korea University Guro Hospital and the Department of Neurology of Samsung Seoul Hospital

An analysis of the effects of stress, metabolic syndrome, and Alzheimer’s disease

Even if your BMI is over 25, it has little effect if you suffer from just one metabolic disease.

A study showed that even if you are obese based on body mass index (BMI), if you suffer from just one metabolic disease, your chances of developing Alzheimer’s are low.

A joint research team led by Kang Seong-hoon, professor of neurology at Korea University Guro Hospital, and Seo Sang-won, professor of neurology at Samsung Hospital Seoul, announced on the 15th that this is the result of a mini- study of the effects of stress and metabolic syndrome on the accumulation and progression of Alzheimer’s disease-causing substances.

Alzheimer’s is the most common degenerative brain disease that causes dementia. It was already known that body weight is related to the symptoms of Alzheimer’s disease. However, no previous study has been done to determine the effect on the symptoms of Alzheimer’s disease by considering metabolic syndrome, which is closely related to obesity.

The research team divided 1,736 Koreans aged 45 or older without dementia into three groups: overweight, normal weight, and obese. Based on the body mass index (BMI), which is weight (kg) divided by height squared (㎡), a BMI of less than 18.5 kg/m2 was classified as overweight, a BMI between 18 and 25 kg / m2 is classified as normal weight, and a BMI of more than 25 kg / m2 is classified as obese. Each group was divided into a metabolic health group and a metabolic syndrome group according to metabolic syndrome criteria, and then the results of amyloid positron emission tomography (PET), brain magnetic resonance imaging (MRI), and cognitive function testing were analyzed. study. If you have one or more of the metabolic syndrome diagnostic criteria without waist circumference, such as high blood pressure, high fasting blood sugar, high triglycerides, and low high-density lipoprotein (HDL) cholesterol, you are in the ‘ metabolic health group.

As a result of the analysis, the positive level of beta amyloid protein, known as the causative agent of Alzheimer’s disease, was 73.9% in the overweight group, which was lower than 37.0% in the obese group. It can be assumed that obesity reduces the accumulation of amyloid. The positive levels of beta amyloid protein in the metabolic health obesity group and the metabolic syndrome obesity group were 29.6% and 42.5%, respectively. The metabolically healthy obese group had thicker hippocampal volume, higher cognitive function scores, and had the slowest decline in cognitive function during long-term follow-up. In summary, the research team believes that the effect of obesity in preventing amyloid accumulation is only effective when the person is metabolically healthy.

Professor Kang said, “Through this study, it was determined that the presence or absence of metabolic syndrome affects the relationship between body weight and Alzheimer’s symptoms,” adding, “Weight and syndrome can metabolic correction through diet, exercise, and medications, thus maintaining metabolic health and appropriate weight.

This study was published in the latest issue of Alzheimer’s Research & Therapy, a prestigious international journal in the field of Alzheimer’s disease.