The report was published in the journal Nature on December 6, 2023, in the article N1- methylpseudouridylation of mRNA causes +1 ribosomal frameshifting. From the working groups of Cambridge and Oxford universities, as listed, whose history and work can be searched The field expertise of these researchers (Thomas E. Mulroney, Tuija Pöyry, Juan Carlos Yam-Puc, Maria Rust, Robert F. Harvey, Lajos Kalmar, Emily Horner, Lucy Booth, Alexander P. Ferreira, Mark Stoneley , Ritwick Sawarkar, Alexander J. Mentzer, Kathryn S. Lilley, C. Mark Smales, Tobias von der Haar, Lance Turtle, Susanna Dunachie, Paul Klenerman, James ED Thaventhiran, and Anne E. Willis)
where abnormal proteins May be related to autoimmune diseases
At present, it can be seen that there is in-depth information. Behind-the-scenes information about vaccines comes out to us from time to time. As in this article and there were additional interviews from the working group. There were even other experts who were not involved in this report providing additional comments. Revealed in the international media The Epoch Times about the mRNA vaccine, it contains important information to raise awareness about the vaccine. This research has shown that There is a strong possibility that the Pfizer vaccine will produce a protein that many experts are concerned about. Because it is believed that there is a possibility that it can increase the risk of cancer and autoimmune diseases. They found that there was a 1 in 10 chance that Pfizer’s COVID-19 mRNA vaccine would not produce the spike protein but would deviate from it and produce another type of protein. This was caused by an error in the translation of the genetic code due to the Pfizer vaccine altering the sequence of bases on the mRNA.
When talking about this type of vaccine, mRNA is a set of instructions used to make proteins. Therefore, once the vaccine enters the cell, Ribosomes translate the code for mRNA to make proteins. Like the spike protein in COVID-19, if there is an incorrect translation of the code, It will cause the creation of faulty proteins as a result. Sometimes the mistakes are as minor as misspelling a word. But it is possible that a mistake occurred. This can have serious consequences… This mistranslation is called a frameshift and occurs when 1-2 bases of the mRNA are shifted. The nucleotide bases of mRNA are usually translated in groups of three bases each, so any base shift will affect the entire sequence that follows. This will lead to the creation of new proteins.
Jessica Rose (immunologist) wrote on her Substack: Shifting the code translation framework. (Frameshifting) results in the production of a variety of proteins. It is a specific protein or it may be an abnormal protein… mRNA naturally contains the base uridine. But in Pfizer’s mRNA vaccine, N1-methylpseudouridine is used. To make the mRNA durable and not destroyed by the body’s immune system… This change in the nucleotide base on the mRNA is the reason why scientists call this type of mRNA vaccine modified RNA or modRNA. The researchers were able to In summary, this is said: There is no evidence yet that this abnormal protein from the Pfizer vaccine is related to side effects or negative effects in people who get the vaccine. But in the future with the use of mRNA technology, it will be important to design or change the mRNA to reduce the translation window shift. (Frameshifting) this
Of the vaccine tests, only Pfizer showed any abnormalities. In addition to the issue of code translation errors N1-methylpseu douridine also interferes with the translation of mRNA into protein. This leads to the creation of a protein sequence that is shorter than normal. Under normal conditions, the ribosome translates the vaccine’s mRNA code into the spike protein. But if the ribosome detects an abnormality, (difference between uridine and N1-methylpseudouridine) It can stop translation or cause translation errors.
This information, Dr. Adonis Sfera, assistant clinical professor of medicine at Loma Linda University, wrote an email detailing this to The Epoch Times. In this research, Researchers injected mice with the Pfizer and AstraZeneca vaccines and found that the Pfizer vaccine was significantly more likely to produce abnormal proteins.
The researchers also compared the vaccinations in people. By comparing 21 people vaccinated with the Pfizer vaccine to 20 people vaccinated with the AstraZeneca vaccine, it was found that one in three people vaccinated with the Pfizer vaccine had an immune response to the abnormal protein. While it was not found in people who received the AstraZeneca vaccine at all.
Off-target immunity and autoimmunity Although there are currently no reports of clear adverse effects of the Pfizer vaccine, But researchers are concerned about the implications for immunity. Abnormalities of the immune system are very dangerous. Dr. James Thaventhiran (immunologist), one of the leaders in writing this research, has stated that Missing the target of the immune response is something that shouldn’t happen. In this case, it means that the immune system does not target the spike protein, but instead targets other proteins that are made abnormally, as nutritional biologist Marit Kolby has highlighted. Repeat this.
Additionally, many health experts are concerned that those proteins increase the risk of developing autoimmune diseases.
Professor Dr.Vladimir Uversky who is a molecular biologist from the University of South Florida and Dr. Alberto Rubio-Casillas In conclusion, autoimmunity may occur when cells in the immune system begin to attack cells that produce those abnormal proteins. In addition, Dr. Sfera adds that Mistranslated proteins may behave like other proteins in the human body and trigger the production of antibodies. Autoimmunity occurs when the immune system attacks its own tissues. This can occur for many years before symptoms appear. Studies by Aristo Vojdani (immunologist) have shown that spike proteins can cause cross-reactivity. It means that the body targets its own cells. on more than 20 types of tissue to fight against foreign substances which has a similar structure to human proteins
Uversky and Dr. Rubio-Casillas He further told The Epoch Times that the production of abnormal proteins and peptides may increase the risk of cancer. Melanoma cells can induce frameshift proteins to evade detection by the immune system. and they expressed their opinion that It is possible that abnormal proteins from the vaccine’s translation of the mRNA code could trigger survival mechanisms, like cancer cells that escape detection by the immune system.
Unknown proteins in the body Researchers still don’t know exactly what the protein is made of. either in terms of structure or peptide sequence. But in research studies, it was found that there is a chimeric protein (mixed protein). This chimeric protein is created from proteins obtained from 2 genes, or possibly more. Normally, each gene encodes a different protein. The chimeric protein found has a similar structure to the human protein. This may trigger an autoimmune response. Jonathan Engler, a physician and lawyer He is also co-chair of the HART (Health Advisory and Recovery Team) group. The HART group brings together UK academic experts to exchange information and advice on a range of matters linked to COVID-19. told The Epoch Times that no one knows for sure whether the findings are linked to any danger. What is known is that those involved do not appear to have bothered to investigate this possibility. In fact, it is something that everyone should be aware of.
Engler design error It has been said that It is true that the mistranscribed mRNA that is injected into the body is due to a design flaw. However, many experts disagree with Engler’s view, such as Edward Nirenberg, who has criticized Engler’s findings for the reason that I’m worried about this. “People tend to make small things into big things.” Frameshift, although it is an unusual event, can occur in nature. For example, Viral infection That results in the production of protein and is a target of the immune system.
However, the researchers stressed in their paper that there was a possibility of an error in the mRNA sequence used in the vaccine, and Pfizer itself was silent on the matter. or any dispute regarding this matter There is still new information released from time to time about the mRNA vaccine. Everyone must watch this matter closely. Because these things are close to us.
Moreover, the information that comes out has many aspects. It may contain both true or false information. Careful consideration and complete information will help us to be confident and make the right decision to maximize the benefits for ourselves as consumers. This also included finding that the mRNA vaccine did not stay on the injection arm for just two to three days, as the company had claimed. But it can be absorbed into the bloodstream and penetrate cells in every organ. And in addition, the vaccines that are produced are also contaminated. The production process involves removing untreated DNA and the ori gene, including the SV40 promoter, which forces the production of unwanted proteins and causes abnormalities.
Therefore, many phenomena are unexplained in vaccinated people. In Thai people, even though each person received six to eight injections, their health was not perfect and many diseases occurred. That is not explained by being infected with Covid.
2024-03-09 22:51:00
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