12.10.2022 10:42
Vascular diseases: intercellular transporters as a new treatment target
A review article with the participation of the Vienna University of Veterinary Medicine analyzed the current state of research on extracellular vesicles in the human blood and lymphatic system. Consequently, these “intercellular signal transporters” are suitable as biomarkers and potential targets for new strategies in tissue regeneration and for the treatment of numerous vascular diseases. According to scientists, universal scientific standards are urgently needed to advance development.
Vesicles are small, round cell particles. Their job is to transport substances into and out of the cell. The latter, the so-called extracellular vesicles (EVs), can be released by almost any cell and taken up by a large number of cells. These transport vesicles deliver complex information from cell to cell. They are therefore of crucial importance for intercellular communication and for the transmission of biological signals.
New starting point for the identification and treatment of vascular diseases
Scientists from Vetmeduni, the Ludwig Boltzmann Institute (LBI) for Traumatology in collaboration with the AUVA (Allgemeine Unfallversicherungsanstalt) and the Austrian Cluster for Tissue Regeneration then examined the current state of research on an important part of extracellular vesicles. , the extracellular endothelial vesicles. Endothelial cells (“vascular endothelium”) are those cells that line the inside of the blood and lymphatic vessels of humans, but also those of animals.
Study co-author Silvio Kau from the Vetmeduni Institute of Morphology on the current research situation: “The vascular endothelium regulates important signaling pathways that affect blood cells and cells in proximity to vessels and regulate cell adaptation and plasticity endothelial. The molecular signatures and functional properties of endothelial cells reflect their heterogeneity and drive current research to better understand the diversity of physiological and pathological effects of extracellular vesicles of the vascular endothelium. “
Particularly important according to Silvio Kau: extracellular endothelial vesicles are associated with the development and progression of various vascular diseases and are therefore potential biomarkers and clinical treatment targets.
Specific studies and mandatory standards are required
Overall, according to the researchers, there is growing evidence that extracellular vesicles originating from endothelial cells in the blood and lymphatic systems are important for maintaining physiological balance. However, they also play an important role in pathological environments. However, the current state of research is insufficient: “More than anything else, further studies are needed that specifically address the specific molecular characteristics of the vascular bed of extracellular endothelial vesicles. From this we expect a better understanding of the different roles and functions of these signal carriers during biological processes. In addition, special attention should be paid to the isolation and characterization of extracellular vesicles. This in turn calls for general standards in extracellular vesicle research, “says Silvio Kau. The International Society for Extracellular Vesicles (ISEV) also confirms the importance of such guidelines in supporting the research community.
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The authors of the article are members of the Austrian Society for Extracellular Vesicles (ASEV), whose current chair is the latest study author and LBI group leader Wolfgang Holnthoner. A congress will be held at the Paracelsus Medical Private University in Salzburg at the end of October, together with colleagues from the subsidiary (GSEV) from Germany, during which these topics will be discussed with international experts.
The article “Lymphatic and endothelial extracellular vesicles: a story yet to be written” by Johanna Trisko, Johanna Fleck, Silvio Kau, Johannes Oesterreicher and Wolfgang Holnthoner was published in “vita”.
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Information about the Vienna University of Veterinary Medicine:
The University of Veterinary Medicine of Vienna (Vetmeduni) is one of the leading institutions of veterinary medicine, academic education and research in Europe. Its main focus is on the research areas of animal health, food safety, animal husbandry and animal welfare, as well as biomedical foundations. Vetmeduni employs 1,500 people and is currently training 2,500 students. The Vienna Floridsdorf campus has five university clinics and numerous teaching and research facilities. Vetmeduni also includes two research institutes at Wilhelminenberg in Vienna, a teaching and research facility in Lower Austria and a branch in Tyrol. Vetmeduni is in the first world championship: in the world ranking of the University of Shanghai 2022, it is once again ranked among the top ten in the subject “Veterinary Sciences”.
Scientific contacts:
Dr. med.vet. Silvio You
Institute of Morphology
Vienna University of Veterinary Medicine (Vetmeduni)
[email protected]
Original publication:
The article “Lymphatic and endothelial extracellular vesicles: a story yet to be written” by Johanna Trisko, Johanna Fleck, Silvio Kau, Johannes Oesterreicher and Wolfgang Holnthoner was published in “vita”. https://www.mdpi.com/2075-1729/12/5/654
Further information:
https: //www.vetmeduni.ac.at/universitaet/infoservice/presseinformationen-2022/ge …
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