Eunpyeong St. Mary’s Hospital Professor Seong-Hoon Jeong and Professor Jun-Seok Lee’s team conducted a large-scale comparative study targeting approximately 130,000 people.
Patients with inflammatory bowel disease have a higher risk of fractures than the general public, and patients with Crohn’s disease are more vulnerable.
Research has shown that inflammatory bowel disease, which causes inflammation in the intestines for an unknown cause, causing abdominal pain and bloody stool, increases the risk of spinal fractures.
△Professor Seong-Hoon Jeong △Professor Jun-Seok Lee
Long-term use of steroids for treatment, along with the chronicity of inflammatory bowel disease and the aging of the patient population, were identified as major factors affecting spinal fractures.
The research team of Professor Jeong Seong-hoon of the Department of Gastroenterology and Professor Jun-seok Lee of the Department of Orthopedics at Eunpyeong St. Mary’s Hospital of the Catholic University of Korea used data from the National Health Insurance Service from 2008 to 2018 to study the incidence and incidence of spinal fractures in 33,778 patients with inflammatory bowel disease and 101,265 people in the general public. We conducted a large-scale comparative study on risk factors for severity.
As a result of the research team’s analysis of various variables such as the study subjects’ age and gender, comorbidities, whether surgery was performed after spinal fracture diagnosis, and drug treatment status, it was found that the risk of spinal fractures in patients with inflammatory bowel disease was higher than that of the general public.
In particular, among inflammatory bowel disease patients, vertebral fractures occurred more frequently and more severely in Crohn’s disease patients. When the risk of vertebral fractures in the general population was set to 1, there was a significant difference of 1.59 for Crohn’s disease patients and 1.27 for ulcerative colitis patients. The risk of exposure to severe or more severe spinal fractures was also high at 1.82 for Crohn’s disease patients and 1.49 for inflammatory bowel disease patients.
Factors affecting spinal fractures were Crohn’s disease, old age, female sex, high comorbidity index, and long-term steroid use. In the case of steroids, there was a significant difference in the incidence of spinal fractures depending on the duration of use.
Inflammatory bowel disease is a disease in which chronic, recurrent inflammation occurs in the gastrointestinal tract, and Crohn’s disease and ulcerative colitis are representative examples.
Chronic intestinal inflammation causes abdominal pain, diarrhea, bloody stool, and malabsorption of iron, zinc, calcium, and vitamin D, which has serious adverse effects on health. Moreover, steroids and immunomodulators used to treat inflammatory bowel disease can have a negative effect on bone metabolism.
However, until now, it was not known whether the risk and severity of spinal fractures actually differed between patients with inflammatory bowel disease and the general population, or how the patterns differed between patients with Crohn’s disease and ulcerative colitis.
Professor Lee Jun-seok (orthopedics) said, “Spine fractures, which add to the socioeconomic burden of patients, can be caused by osteoporosis due to aging and menopause, but they can also be caused by secondary osteoporosis caused by chronic diseases or drug treatment.” He added, “Inflammatory bowel disease. “This study is of great significance in that it identifies the current status of spinal fractures that occur due to chronic disease or long-term use of certain drugs,” he explained.
Professor Seong-Hoon Jeong (Division of Gastroenterology) said, “Through this study, we specifically confirmed the correlation and risk factors between inflammatory bowel disease and spinal fractures,” and added, “We closely observed the patient’s gender, age, and complexity of concomitant diseases. In addition, active efforts are needed to monitor bone density regularly, provide vitamin D, and reduce the use of steroid treatments.”
Meanwhile, this study was published in the latest issue of the Journal of Korean Medical Science (Impact Factor 4.5), an international journal of the Korean Medical Association, under the title ‘Study on risk factors for the occurrence and severity of spinal fractures in patients with inflammatory bowel disease.’
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2024-01-22 08:31:19
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