leukocyteThese are cells of the body’s immune system that fight cancer, bacteria and viruses. However, not allleukocyteThey can destroy cancer cells On the other hand, someleukocyteIt can even stimulate the growth of cancer cells. The most important thing is to destroy cancer cellsleukocyteThe types are cytotoxic T cells and natural killer cells. Cell types that support cancer cell growth include regulatory T cells and myeloid-derived suppressor cells.
The paper’s first author, Tiia Koivula from the University of Turku, Finland, said: “A different kind ofleukocyteThe balance determines whether the immune system destroys cancer cells or supports them. If there are more cancer-killing cells than cancer-promoting cells at the tumor site, the body is better able to fight cancer. “
Twenty newly diagnosed breast cancer patients who had not started treatment participated in the study. During the study, patients pedaled a bicycle ergometer for 30 minutes against their own choice. theresportforward,sportNeutralizationsportAfter that, the researchers collected blood samples from the patients.
Researchers analyzed blood samples and calculated different types ofleukocytesize and willsportData measured during the period were compared with data at rest.
The results show that there issportWhen, there are several different types in the bloodleukocyteThe number has increased. The number of cytotoxic T cells and natural killer cells, which destroy cancer cells, remained unchanged;
The researchers also looked at it differentlyleukocytewith totalleukocyteBy counting the proportions, it was found that the proportion of natural killer cells increased significantly, while the proportion of myeloid-derived suppressor cells decreased.
“We got that insportDuring the process, cells in the blood destroy cancer cellsleukocyteIncrease in number and proportion, thus promoting the growth of cancer cellsleukocyteThe ratio either stays the same or goes down. However, it is not clear whether these changes observed in the blood are also in the tumor arealeukocyteAccount changes. Koivula said.
“Plus, insportAfter 1 hour, almost all typesleukocyteVolumes are reduced to resting levels. Based on current knowledge, we cannot be sureleukocytetheresportWhere did he go after that, but in preclinical studies, he was found to destroy cancer cellsleukocytemove to the tumor area. ” added Koivula.
The researchers also analyzed whether different types of breast cancer are affectedleukocytefromsportreaction They found that the larger the tumor, the less the number of natural killer cells increased. Patients with estrogen and/or progesterone receptor-positive breast cancer had a smaller increase in cytotoxic T cells than patients with receptor-negative breast cancer.
“In previous research, we found signs that the type of breast cancer may have an effectsportrightleukocyterole, which is why we wanted to investigate further. “However, we found that the correlation was not very strong, so no strong conclusions can be drawn from the results,” said Koivula. Exercise is known to benefit all cancer patients, and our recent research supports this idea.”
Related paper information:
https://doi.org/10.3389/fimmu.2024.1394420
2024-08-21 11:30:48
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