“There are monoclonal antibodies that block this PCSK9 in the blood and, in just two days, LDL is already at its lowest level”, compares Raul Dias dos Santos, a Brazilian who is considered one of the greatest authorities in the world when it comes to cholesterol. “But their effect doesn’t last long and, fifteen days later, you already need a new injectable dose. With inclisiran, however, it’s not like that”, says he, who is a professor at the Faculty of Medicine at USP (University of São Paulo) and researcher at Hospital Israelita Albert Einstein, in the capital of São Paulo.
To begin with, inclisiran does not stop PCSK9 ready-to-go like monoclonal antibodies do and, rather, cuts the production of this molecule in the bud, inducing the liver to temporarily close its factory. But the biggest advantage of all is that its effect lasts. Oh, if it lasts… “So much so that the person only needs to get a new injection 90 days after the first injection and then, six months later, take another one. In other words, there are three applications in the first year and, from then on, hence, we only prescribe two injections every six months”, says Raul Dias.
Therefore, while those with high cholesterol must take statins every day and repeat the dose of monoclonal antibodies every 15, inclisiran makes it easier, because you only need to remember it twice a year. “With the difficulty we have for patients to adhere to treatment, this is quite a positive point”, comments doctor Fabrício Assami Borges, who coordinates intensive therapy and cardiology at Hospital Santa Paula, in São Paulo, which belongs to Dasa .
To lower cholesterol
Basically, all the drugs used to lower LDL levels in the blood will act on the liver, increasing its ability to remove circulating particles of this substance before they are deposited on the walls of the vessels and, little by little, block the blood flow. .
“Statins, for example, block part of the production of cholesterol in the liver itself”, explains professor Raul Dias. “And, as this organ needs cholesterol, this causes its cells to increase the number of receptors to capture the LDL that is in circulation.” In other words, at the end of the day, bad cholesterol leaves the vessels and ends up in the liver.
2023-10-31 08:36:13
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