[유영현의 의학 논문 속 사람 이야기]
Entered 2024.01.10 16:00 Views 174 Entered 2024.01.10 16:00 Modified 2024.01.09 09:19 Views 174
논문 24: Kim HY, Park SY, Lee MH, Rho JH, Oh YJ, Jung HU, Yoo SH, Jeong NY, Lee HJ, Suh S, Seo SY, Cheong J, Jeong JS, Yoo YH. Hepatic STAMP2 alleviates high fat diet-induced hepatic steatosis and insulin resistance. J Hepatol. 2015;63:477-485.
■Person: Hyeyoung Kim (Research Professor)
■Academic significance: The role of STAMP2 in high-lipid diet-induced fatty liver disease
In my late 30s, I pioneered the field of ‘cell death’ and had already achieved some level of success, but the wind of upheaval blew again. It was around the early 50s.
Dr. Hyeyoung Kim, who joined my room as the sixth research professor, wanted to conduct research on lipid metabolism. If I accepted this proposal, the focus of my laboratory’s experiments would have to shift to lipid metabolism research using animal models, which induces fatty liver disease through long-term high-lipid diets.
As I entered cell death research, more changes were required than when I transformed from a researcher of morphology to a researcher of cell and molecular biology. I did not have the confidence to undertake research that was incomparably more complicated than previous cell death research.
A conflict arose. But I decided to trust Dr. Kim. Dr. Hyeyoung Kim had good experience in molecular-level research under the guidance of her molecular biology advisor.
I proposed, following my laboratory’s policy, to study lipid toxicity in a reservoir called cell death. This was a somewhat unreasonable proposition since lipids are not highly toxic. Dr. Kim accepted this unreasonable proposal, and my room began conducting ‘high-risk, but high-value’ lipid toxicity research.
Cell death is pushed to the back, and lipid metabolism moves to the front.
A study that was completely different from the main research in my lab so far began. Once the research began, research on cell death due to lipid toxicity was pushed aside and the focus was on studying abnormalities in lipid metabolism. From this point on, my principle of ‘conducting research swimming in the reservoir of cell death’ was not followed.
Still, the data produced was so interesting and valuable that I was helplessly caught up in this research. My studies also expanded beyond the cell death reservoir and into the area of lipid metabolism.
As meaningful data was added, I started writing the paper even though the data was not fully available, so that Dr. Kim could concentrate on the experiments without the burden of writing the paper.
On days when animal test results, which required a long time, were obtained, all 10 people in my laboratory were mobilized to analyze blood and remove tissues from dawn to night. There was applause when the mouse’s stomach was opened. Clear data poured out to prove our hypothesis.
This paper was submitted to ‘J Hepatol’, the leading journal in the liver field, and was accepted without modification and recognized for its value. The thesis was also registered in Hanbitsa (People who make Korea shine).
Dr. Kim received the Amore Pacific ‘Next Generation Researcher Award’ for this paper. For this paper, I received the Uidang Academic Award, given to a professor of basic medicine nationwide. I don’t study to win awards, but my achievements shine most strongly when I receive them.
Dr. Hyeyoung Kim (second from the left) attending the Amorepacific Next Generation Researcher Award ceremony. [사진=유영현 제공]
Kim Hye-young, who changed the lab theme… Still, the ‘Seposa’ reservoir remains.
Afterwards, lipid metabolism research became the main research field in my room, and I mainly produced achievements in the field of lipid metabolism until the end of the research.
After moving from cell death research to lipid metabolism, many fellow researchers asked me why I left cell death research and moved to metabolism research. At a time when cell death research was rare, an answer was lacking.
However, while conducting lipid metabolism research, I did not burst the dam of the cell death research reservoir. Subsequent lipid metabolism research included research on cell death caused by lipid toxicity, and my research reservoir “cell death” was eventually maintained.
When I started researching the mechanisms of cell death in the mid-90s and when I started studying lipid metabolism in the early 2010s, it was a turning point in my research that included both crises and opportunities. If I had to interpret it, I got through this transition well because I did not try to protect my identity and showed a flexible attitude.
However, it is not the perception and action of identity or flexibility that produces results. Looking back, I passed both periods due to inexplicable luck. Research is also one of the three skills of luck!
editor
“Copyright ⓒ ‘Honest Knowledge for Health’ Comedy.com ( / Unauthorized reproduction and redistribution prohibited”
2024-01-10 07:23:40
#Research #unchilgisam #Comedy.com
