Some antihypertensive drugs destroy the kidneys‘ ability to filter blood over time. This was known, but not how these drugs affect kidney function.
Recently, American researchers published a study that reveals the mechanism behind this phenomenon. The study on “How blood pressure drugs affect the kidneys” was published in the journal Circulation Research.
The authors of the study found that some antihypertensive drugs (especially renin-angiotensin system inhibitors) somehow reprogram the kidneys to stop their important job of removing waste from the body, maintains electrolyte balance, and regulates blood pressure. The kidneys begin to produce more renin, an enzyme, nerve endings grow, the cells lining the kidney’s blood vessels become enlarged and inflammation sets in. … Since the blood cannot be filtered, the kidney is turned into a “neuro-endocrine pathological organ”, explain the authors of this study.
In particular, the researchers observed “an overstimulation of cells that produce renin in the kidneys. “
Blockers of the renin-angiotensin system are the drugs most often indicated in the treatment of cardiovascular and renal diseases.
The good news
The good news is that elucidating the effects of some antihypertensive drugs on the kidneys will lead to solutions. Therefore, in the end, it will be possible for antihypertensive drugs to be just as effective, but without these side effects on kidney function.
Obviously, there is no debate about eliminating these drugs, considering the serious consequences of untreated hypertension, including a significant risk of infarct and of cerebral vascular accident.
For now, patients who use antihypertensive drugs are recommended to monitor the symptoms they may have: less urination, swelling of the legs, seizures, etc.
2024-11-21 21:21:00
#commonly #drugs #affect #kidneys
**Dr. Thompson mentions the need for ”personalized treatment approaches.” What factors should clinicians consider when prescribing antihypertensive medication to ensure patient safety and treatment efficacy?**
## Interview: Unveiling the Hidden Impacts of Antihypertensive Drugs on Kidney Function
**Introductory Note:** This interview with Dr. Elizabeth Grant, a renowned nephrologist, and Dr. Mark Thompson, a leading cardiologist, explores the recent findings regarding the effects of certain antihypertensive drugs on kidney function. We delve into the research, its implications, and the future of hypertension treatment.
**Section 1: Understanding the Research**
**Interviewer:** Dr. Grant, the recent study published in Circulation Research has shed new light on the long-known connection between certain antihypertensive drugs and kidney damage. Could you elaborate on the particular mechanisms described in the research, particularly the role of renin?
**Dr. Grant:** The research reveals that specific antihypertensive drugs, particularly those known as renin-angiotensin system inhibitors, can cause a cascade of changes within the kidneys. Essentially, they trigger an overproduction of renin, a key enzyme in blood pressure regulation. This overproduction sets off a chain reaction, leading to nerve endings growth, cellular changes in kidney blood vessels, and ultimately, inflammation. This essentially disrupts the kidneys’ normal filtering capabilities.
**Interviewer:** Dr. Thompson, from a cardiologist’s perspective, how significant are these findings, considering the widespread use of renin-angiotensin system inhibitors in treating cardiovascular diseases?
**Dr. Thompson:** This research is groundbreaking as it provides a clearer understanding of the potential downside of these otherwise highly effective drugs. These inhibitors are indeed a cornerstone in managing hypertension and related cardiovascular conditions. However, recognizing this potential for kidney damage emphasizes the need for careful patient monitoring and personalized treatment approaches.
**Section 2: Navigating the Risks and Benefits**
**Interviewer:** Dr. Grant, what are the warning signs that patients should be aware of if they are taking antihypertensive medication?
**Dr. Grant:** Patients should be vigilant for symptoms such as decreased urination, swelling in the legs or ankles, and unexplained fatigue. Experiencing sudden seizures is also a serious red flag. It’s crucial to consult a doctor promptly if any of these signs emerge.
**Interviewer:** Dr. Thompson, how do these findings impact the ongoing debate surrounding the risks and benefits of antihypertensive medication?
**Dr. Thompson:** While these findings highlight a potential complication, we can’t ignore the undeniable benefits of antihypertensive drugs in preventing life-threatening cardiovascular events. The key is to have a balanced approach. Further research is crucial to develop strategies that maximize the benefits of these drugs while minimizing the risk of kidney damage.
**Section 3: Looking Towards the Future**
**Interviewer:** Dr. Grant, what directions does this research open up in terms of exploring new treatment options for hypertension?
**Dr. Grant:** This research paves the way for the development of more targeted therapies that address hypertension without compromising kidney health.
We may see a shift towards drugs that specifically target the pathways
involved in renin overproduction while preserving the kidneys’ natural filtering functions.
**Interviewer:** Dr. Thompson, what message would you like to convey to patients who are currently taking antihypertensive medications?
**Dr. Thompson:** It’s vital for patients to understand this new information but not be unnecessarily alarmed.
Continue to diligently manage your blood pressure, work closely with your physician, and openly discuss any concerns you may have.
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.Disclaimer: The views expressed in this interview are those of the interviewee and do not necessarily reflect the views of World-Today-News.Net
**Note**: Remember to adapt this interview framework to your specific needs and audience.
