Home Urine Test Study Finds 3% of Participants Have Elevated Albuminuria: Research by Gansevoort et al.

Just over three percent of the participants in a home urine test study have elevated albuminuria. This is according to research by Gansevoort et alpublished in The Lancet.

For this study, 15,074 people between the ages of 45 and 80 were randomized (1:1) to a home test to determine the albumin/creatinine ratio. One half collected urine and sent it to a laboratory (the UCD method) and the other half performed the determination themselves using a urine dipstick and a smartphone app. Participants with elevated albuminuria were sent a second test, and if this test was also positive, they were referred for more extensive diagnosis of chronic kidney damage and cardiovascular risk factors.

Screening

The primary outcome measure was the willingness to participate and the yield of the home test and the more extensive screening. The percentage of participants in the UCD method was 59.4% and in the app method 44.3%. Elevated albuminuria was confirmed in 150 of 4483 (3.3%) participants in the UCD method and in 171 of 3336 (5.1%) participants in the app method. With a sensitivity of 96.6% and a specificity of 97.3%, the UCD method is more suitable for screening than the app method, which has a sensitivity of 98.1% and a specificity of 67.9%. Of the 124 participants in the UCD method who also underwent more extensive screening, 111 people (89.5%) were referred to their GP for newly diagnosed renal failure, cardiovascular risk factors, or risk factors that were already known.

30 people would have to be screened to show 1 person with elevated albuminuria. To determine a new elevated albuminuria, 58 people need to be screened.

Ron Gansevoort of the UMC Groningen states in a press release: ‘This is an important step towards population screening for kidney damage.’

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2023-08-25 07:03:00
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