Home » Health » HKU Faculty of Medicine develops nano-drug delivery system to help treat obesity and atherosclerosis | Social Affairs

HKU Faculty of Medicine develops nano-drug delivery system to help treat obesity and atherosclerosis | Social Affairs

The research team of the Li Ka Shing Faculty of Medicine of the University of Hong Kong (HKU Faculty of Medicine) has developed nanoparticles loaded with thyroxine (Thyroid hormone, TH). The severe side effects associated with systemic delivery of TH are expected to advance the development of treatments for obesity and its complications. The findings have been published in the journal Nature Communications (Click here to browse journal articles)。

HKU Faculty of Medicine research team develops nano drug delivery system to help treat obesity and atherosclerosis. Members of the research team include (from left) Dr Zhang Yaming, Dr Zhang Liyi, Wang Qin, Dr Wang Weiping, Dr Jin Leigang, Professor Xu Aimin and Dr Chen Kang.

Background information

Obesity can lead to life-threatening chronic diseases such as diabetes, cardiovascular disease and neurodegeneration. TH is a very old hormone that can promote energy expenditure and has certain potential for the treatment of obesity and its complications. Although researchers have made great efforts in the past few decades, clinical trials have not yet proved that chronic systemic injection of TH has a significant weight loss effect on obese patients. At the same time, due to the wide distribution of TH receptors, systemic injection of TH usually leads to a variety of serious side effects, including tachycardia, heart disease, muscle atrophy and osteoporosis. In addition, although adipose tissue and skeletal muscle are considered to be the two main target organs for TH to increase metabolic rate and promote energy expenditure, whether TH can exert its weight loss effect only through adipose tissue remains to be proved.

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