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Association Between Heat exposure and Kawasaki Disease: A Time-Stratified Case-Crossover Study
Table of Contents
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- Association Between Heat exposure and Kawasaki Disease: A Time-Stratified Case-Crossover Study
- Heat-related impacts on all-cause emergency hospitalisation differ by age and sex: a time-stratified case-crossover study
- Association Between Heat Exposure and Anaphylaxis in Japan: A Time-Stratified case-Crossover Study
- Heat Exposure and Its Impact on Health: An Interview with Dr. Nobutoshi Nawa
Source: PubMed
URL: Link
As the exposure of interest includes heat, hospitalizations during the five warmest months (May through September) were used for analysis. A time-stratified case-crossover study with conditional quasi-Poisson regression analysis was used to estimate the relative risk (RR) of weather exposure for Kawasaki disease hospitalization with a lag of …
Source: Journal of Epidemiology & Community Health (JECH)
URL: Link
Days of heat exposure were defined as days when the daily mean temperature exceeded the minimum morbidity temperature (ie, temperature with the lowest relative risk between the 25th and the 75th percentiles of the daily mean temperature distribution). …
Authors:
- Nobutoshi Nawa
- Tomoki nakaya
- Kiyohide Fushimi
- …
Funding: This work was …
Association Between Heat Exposure and Anaphylaxis in Japan: A Time-Stratified case-Crossover Study
Source: Allergy
URL: Link
Nawa and colleagues collected 2011 – 2022 daily hospitalization data for anaphylaxis from a nationwide administrative claims database. Data on daily average temperature came from the Japan Meteorological Agency. The study focused on hospitalizations during the 5 warmest months: May to September.
“Further research is needed to identify underlying mechanisms of the association,” investigators concluded.
References:
- Nawa N,Nishimura H,Fushimi K,Fujiwara T.Association between Heat Exposure and Anaphylaxis in Japan: A Time-Stratified Case-Crossover Study. Allergy.2025 feb 1. doi: 10.1111/all.16488. Epub ahead of print.: 39891474.
- Lam HCY, Turner PJ, Hemming D, Jarvis DL. Seasonality of Food-Related anaphylaxis Admissions and Associations With Temperature and Pollen Levels. Journal of Allergy and Clinical Immunology. In Practice 9, no. 1 (2021): 518–520.e2.
- Lee SY, Lee SC, Shin SD, et al.Epidemiology and Outcomes of Anaphylaxis-Associated Out-Of-Hospital Arrest. PLoS One 13, no. 3 (2018): e0194921.
Authors:
- Nobutoshi Nawa (Corresponding Author)
- Hisaaki Nishimura
- Kiyohide Fushimi
- …
Affiliation:
- Department of Public Health, Institute of Science Tokyo, Tokyo, Japan
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Heat Exposure and Its Impact on Health: An Interview with Dr. Nobutoshi Nawa
As weather conditions become more extreme, the implications on public health have never been more pressing. Recent studies have explored the link between heat exposure and adverse health outcomes, particularly focusing on diseases like Kawasaki disease and conditions such as anaphylaxis. World Today News’s senior editor recently sat down with Dr. Nobutoshi Nawa, a renowned specialist in public health, to discuss these emerging findings.
Exploring the Association Between Heat Exposure and kawasaki Disease
Editor: Your study highlighted the connection between heat exposure and Kawasaki disease. can you elaborate on your findings and their implications?
Dr. Nobutoshi Nawa: Certainly. We analyzed hospitalizations during the five warmest months, from May thru September. Our study identified a important relationship between higher daily mean temperatures and increased hospitalizations for Kawasaki disease.This suggests that elevated temperatures might trigger or exacerbate the condition, which is particularly crucial for understanding pediatric health in warmer climates.
The Temperature Threshold for Heat Exposure and Morbidity
Editor: How did you define heat exposure in your recent study published in the Journal of Epidemiology & Community Health?
Dr. Nobutoshi Nawa: We defined days of heat exposure as days when the daily mean temperature exceeded the minimum morbidity temperature — essentially, the temperature with the lowest relative risk between the 25th and the 75th percentiles of the daily mean temperature distribution. This metric allows for a more nuanced understanding of how varying degrees of heat influence emergency hospitalizations, differing by age and sex.
Connecting Heat Exposure to Anaphylaxis in Japan
Editor: Your work in Allergy examined the association between heat exposure and anaphylaxis in Japan. What were your primary findings and what do they mean for public health strategies?
Dr. Nobutoshi Nawa: Our study collected daily hospitalization data from 2011 to 2022 and compared it with daily average temperatures. We observed that during the warmest months — May to September — there was a notable rise in anaphylaxis hospitalizations. This suggests that heat might play a role in triggering anaphylactic episodes, further emphasizing the need for heat-related health advisories and interventions.
Future Research and Policy Implications
Editor: What are the next steps for your research, and how can policymakers leverage this information?
Dr. Nobutoshi Nawa: Further research is required to identify the underlying mechanisms of these associations. Policymakers can use this data to implement early warning systems, provide public guidance on heat-related health risks, and even adjust healthcare resource allocation to better handle increased demand during heatwaves.
Editor: Dr.Nawa, thank you for your insights and the thought-provoking research you’ve contributed to the field.
Dr. Nobutoshi Nawa: Thank you.It’s significant to continue investigating these issues to improve public health outcomes, especially as temperatures continue to rise globally.
Link to Study on Heat and Kawasaki Disease
Link to Study on Heat-related Impacts on Hospitalization
link to Study on heat and Anaphylaxis
