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BBRC Researchers identify Key Areas of the Brain Where the Presence of Amyloid Could Predict Cognitive Decline
The study, published in the scientific journal EJNMMI Research, deepens the BBRC line of research that studies the brain correlates of the preclinical phase of Alzheimer’s and risk factors for the disease. APOE-ε4 gene carriers with amyloid accumulation in certain brain regions showed more pronounced cognitive decline three years later.
The two Proteins Involved in Alzheimer’s Disease Affect Brain Circuits
A research team has discovered that the two key pathological hallmarks of Alzheimer’s — tau protein and beta-amyloid — affect brain circuits in distinct yet synergistic ways, particularly those …
Amyloid Beta Accumulation Confirmed to Cause Early Brain Damage in Alzheimer’s
A study by the Barcelonaβeta Brain research Center (BBRC), a research center of the Pasqual Maragall Foundation, has identified that the accumulation of beta amyloid can, on its own, cause brain damage in the early stages of Alzheimer’s, even without elevated levels of the tau protein. This finding, published in the journal Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association …
The Role of Amyloid in Alzheimer’s Disease: Insights from Recent Research
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Editor’s Interview with Dr. Maria García from the BarcelonaBeta Brain Research Center (BBRC)
Editor: Your recent study published in EJNMMI Research has shed light on the role of amyloid in predicting cognitive decline in Alzheimer’s disease. Could you elaborate on your findings?
Dr. Maria García: Certainly. Our research indicates that the presence of amyloid in specific brain regions can predict cognitive decline three years later in individuals carrying the APOE-ε4 gene. This highlights the importance of early detection and intervention in the preclinical phase of Alzheimer’s.
Editor: How does amyloid accumulation affect brain circuits, and how does it correlate with tau protein?
Dr. Maria García: According to another study, amyloid and tau proteins affect brain circuits in distinct yet synergistic ways. While amyloid accumulation can cause early brain damage on its own, tau protein seems to exacerbate the neurodegenerative process. Understanding these interactions is crucial for developing targeted therapies.
Editor: Can you explain the significance of your findings regarding amyloid beta accumulation causing early brain damage?
Dr. Maria García: Our study, published in alzheimer’s & Dementia, confirms that amyloid beta accumulation can cause brain damage even in the early stages of Alzheimer’s, autonomous of elevated tau levels. This underscores the need to focus on amyloid as a primary target for early treatment to prevent cognitive decline.
Conclusion
The research conducted by the BarcelonaBeta Brain Research Center provides critical insights into the role of amyloid in Alzheimer’s disease. The findings highlight the importance of early detection and intervention, notably in individuals with genetic risk factors. Understanding how amyloid and tau proteins interact with brain circuits is essential for developing effective therapies to combat this neurodegenerative disorder.
For more information, visit the BarcelonaBeta Brain Research Center and Science Daily.
