A likely factor in the onset of Alzheimer’s disease is the accumulation of molecules called amyloid peptides. They cause cell death and are often found in the brains of Alzheimer’s patients. Now, Swedish scientists have shown that these accumulations can be reduced when exposed to graphene oxide.
True, the experiments were carried out on yeast cells with amyloid clumps, but scientists at Chalmers University of Technology in Sweden are optimistic.
“Our study also explains the mechanism behind the effect. Graphene oxide affects cell metabolism in a way that increases their resistance to protein and oxidative stress. Such a thing has never been observed before,” said Xin Chen, lead author of the study, according to EurekAlert.
“The yeast cells in our model resemble neurons affected by the accumulation of beta-amyloid42, a form of amyloid peptide most prone to aggregation. These cells age faster than normal, exhibit stress and mitochondrial dysfunction, and an increased production of harmful reactive oxygen radicals,” the scientist added.
Graphene oxide nanoflakes, as used in the experiment, are two-dimensional carbon nanomaterials with unique properties, including increased biocompatibility and amazing conductivity. They are used in various research projects, including the development of cancer treatments and biosensors.
They are also water soluble and interact well with biomolecules such as proteins. When penetrating into living cells, graphene oxide is able to influence protein accumulation processes.
“As a result, it can hinder the formation of protein aggregates and promote the disintegration of existing aggregates,” explained Santosh Pandit, author of the study and researcher in biological systems.
There is currently no cure for Alzheimer’s. It is estimated that more than 40 million people worldwide are living with Alzheimer’s or some form of dementia.
2023-10-10 21:02:00
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