Gout is a common form of arthritis characterized by pain and inflammation in the joints. Caused by the deposition of excess uric acid in the body, gout can be extremely painful. There are several risk factors that can contribute to this disease, such as genetic, medical and behavioral.
Find out in this article details about the risk factors for gout.
Genetic risk factors
read here the most important information you need to know about gout. The first genetic factor associated with this disease is the genetic variations that can cause an increase in the levels of uric acid in the blood. These variants of the gene can contribute to increased levels of uric acid and therefore an increased risk of gout. [1]
The second genetic factor that can contribute to gout is genetic mutations that affect the body’s ability to metabolize uric acid. This can lead to the excessive accumulation of acids in the body and implicitly to an increased risk of gout. [2, 3]
Medical risk factors, such as chronic diseases
Kidney diseases are the most common medical condition associated with gout. They are characterized by a decrease in renal function and disorders of uric acid metabolism. This leads to an increase in uric acid levels in the blood, which can cause or worsen gout symptoms. [1]
Cardiovascular diseases also play a role in the risk of developing gout. People with a history of cardiovascular disease or with risk factors for cardiovascular disease (such as diabetes, obesity and smoking) are more exposed to the occurrence of this condition. High levels of uric acid can damage blood vessels and contribute to high blood pressure. [3]
High blood pressure is another medical risk factor associated with gout. It increases blood pressure above levels considered healthy. High blood pressure levels can contribute to elevated uric acid levels and can be an indicator of an underlying metabolic problem. [2]
Behavioral risk factors, such as diet and lifestyle
Behavioral risk factors for gout, such as diet and lifestyle, can have a significant impact on your health. Eating foods rich in purines and dairy products, such as red meat and cheese, can contribute to increasing blood uric acid levels. This can increase the likelihood of gout. Excessive alcohol consumption can have the same effect on blood uric acid levels. [1]
Also, obesity, sedentary lifestyle and lack of physical activity can contribute to the increase of uric acid levels in the blood. Being overweight can cause the body to produce more uric acid and create the perfect conditions for gout symptoms. It is very important to do regular exercises, which help to keep body weight under control and prevent gout symptoms. [1, 3]
In addition, if you consume carbonated drinks often, it is recommended to do so in small doses. Carbonated drinks often contain sodium, which can increase fluid retention in the body and cause inflammation and swelling of the joints. This can lead to increased levels of uric acid in the blood. [2]
Gout is a chronic painful disease that affects the joints. Its causes are often related to diet or an unhealthy lifestyle. If you present symptoms specific to gout, it is recommended to go to a medical check-up to be evaluated and to receive the appropriate treatment. Self-medication is not recommended or encouraged.
Sources:
Ragab, Gaafar et al. “Gout: An old disease in new perspective – A review.” Journal of advanced research vol. 8,5 (2017): 495-511. Accesat pe 9 februarie 2023, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512152/
Igel, Talia F et al. “Recent advances in understanding and managing gout.” F1000Research vol. 6 247. 10 Mar. 2017, Accessed February 9, 2023, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357039/
Grassi, W, and R De Angelis. “Clinical features of gout.” Rheumatism vol. 63,4 238-45. Jan 19 2012, Accessed February 9, 2023,
