The reds from Manchester showed strength against Barcelona on Thursday, where they made a strong turnaround. The victory gave advancement to the round of 16.
There they will face Real Betis. The first match will be played at Old Trafford.
The last time the teams met was in a friendly match on December 10, last year. Then it ended 1-0 to the Spaniards. During this match, both teams were missing key players, as the World Cup in Qatar was underway.
Manchester United are looking for their second Europa League trophy, after winning the tournament for the first time in 2017. The Reds are currently in superb form and are third in the Premier League.
Real Betis are in a strong fifth place in La Liga, and have won their last two matches. The green and whites did not lose a single game in their group stage in the Europa League, and ended up beating Italian Roma, among other things.
Portugal trip for Ødegaard
Martin Ødegaard and the rest of his Arsenal will face Sporting Lisbon in their round of 16 final.
The Gunners currently top the table in the Premier League, and face a Sporting team that easily progressed against Danish Midtjylland in the round of 16.
The first match between the big clubs will be at Sporting’s home ground, Estádio José Alvalade.
The other matches in the round of 16 are:
Union Berlin-Union Saint Gilloise
Sevilla-Fenerbahce
Juventus-Freiburg
Bayer Leverkusen-Ferencevaros
Rome-Royal Society
Shaktar Donetsk-Feyenoord
All matches will be played on 9 and 16 March.