The problem occurs with vector vaccines, such as those of AstraZeneca and Johnson & Johnson – although very rarely. There have been cases of cerebral thrombosis in a number of countries, including Germany. German scientists now believe they have found the cause and way to adapt vaccines to prevent blood clots.
So far there was no explanation for the problem
Cerebral venous sinus thrombosis (CVST) and splanchnic vein thrombosis (SVT) after vaccination are the result of thrombocytopenia, a condition in which a person has a low platelet count.
In a reprint yet to be reviewed, a team at the University of Frankfurt said that while scientists had already proposed a mechanism to explain vaccine-induced thrombocytopenia, there was still no satisfactory explanation for blood clots.
It all started with the delivery of the Sars-CoV-2 spike protein gene. In vector vaccines, it is delivered through an adenoviral system, the researchers wrote. The SARS-CoV-2 gene is then transcribed inside the nucleus and subsequently exported as mRNA therefrom. Arriving in the cytosol (the fluid contained in the cells), the mRNA is again transformed into a spike protein.
“And that’s where the problem lies,” the scientists wrote. “The viral part of DNA, an RNA-derived virus, has not been optimized to be transcribed inside the nucleus,” explains Rolf Marshalek, one of the study’s authors.
The vaccine can be modified
When the process of splicing (elimination of gene introns) takes place in the nucleus, it can lead to the destruction of the “reading frame” and the production of atypical proteins in the cytosol.
Marshalek says the vector vaccine can be slightly modified to create a safe spike gene that will not allow the production of abnormal proteins.
After studying the available information on individual vaccines, including the known side effects of those of Janssen and AstraZeneca, the researchers believe that the problem is mainly with the preparation of AstraZeneca. They have already contacted Johnson & Johnson and hope that AstraZeneca will also respond.
The material has been published HERE >>
–
