“Genomics” prevents diseases precisely Reduce the burden of treatment costs

Thailand’s integrated medical industry is worth about 560 billion baht, growing at an average of 13.7 percent annually, including modern medical services. The value of the medical device industry is about 368 billion baht The medical device industry is worth about 040 billion baht It is worth about 152 billion baht, the value of the precision medicine market worldwide in 2018. 2019, more than 30 billion dollars and is expected to increase to 48 billion dollars in 2024, or an average growth of 9.7% per year.

“Genomics“This is one of the world’s medical innovations in personalized treatment. (Personalized) designing medicines that respond to the treatment of each person effectively, predicting and diagnosing disease correctly (Prediction) even if it is a disease that is difficult to treat, and planning treatment (prevention) appropriately regardless of the current disease. or diseases that are expected to occur in the future

Thailand has introduced this innovation to diagnose, treat and prevent gene mutations in various types of cancer cells. to provide treatment and medications that meet the needs of each patient Helping to reduce side effects from traditional treatment. and help extend patients’ lives

For example, Angelina Jolie was found to have a genetic, or DNA, mutation. This led to a chance of death and DNATest found that there was an 87% chance of breast cancer and a 50% chance of ovarian cancer, so they decided to do breast surgery.

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Thailand Genomics Action Plan

The Cabinet decided to approve Thailand’s Integrated Genomics Action Plan 2020–2024 onwards

on March 26, 2019 to lead the development of genomic medicine in the country Give Thai people access to medical servicesGenomics including the creation of the country’s infrastructure This will be an important foundation that will continue as a leader in business centers and medical services in the ASEAN region.

Whether it is the National Biological Resource Center, the Genomics Medical Testing Service Center in the Eastern Special Development Zone and the National Genome Information Center, push for medical genomics services to be included in the Office benefits package National Health Security (NHSO) and push the country to become a medical center in the ASEAN region. Encourage investment and medical tourism (Medical Tourism) which will help revitalize the country’s economy and society.

35,000 people have been genetically tested.

According to Thailand’s Integrated Genomics Action Plan (Genomics Thailand) 2020-2024, the goal isEncoding the genetic code50,000 Thai people were divided into 5 groups to make the data statistically effective. Among them infectious diseases chronic non-communicable diseases cancer group Unknown and rare diseases Pharmacogenetics group Preventing drug allergies and choosing the right medicine or drugs related to genes Currently, more than 35,000 have been to test a person for genetic codes. Then it is sent for genetic encoding. This allows for timely, in-the-moment, genetic testing

with the National Science and Technology Development Agency (NSTDA) taking care of infrastructure issues. In data management, an overview of technology developing systems for data storage, processing and management. and extract only information related to mutations. Help make operations more convenient and easier under the budget of 4,470 million baht to make Thailand a leader in Genomic Medicine at the ASEAN level within 5 years.

Decode the genetics of 1,500 people every month

“Dr. Sisadet Thongsima” Director of the National Bioresources Bank National Science and Technology Development Agency (NSTDA), the subcommittee and deputy secretary of the subcommittee in charge of the Thailand Integrated Genomics Action Plan, gave an interview:Bangkok Thurakit” that we are currently recruiting around 2,000 volunteers to reach the required number of 50,000 as it takes time to select volunteers to join the project. and they must rely on doctors who are in the medical group’s research network

In addition, theEncoding the genetic codeThe process is very complex and can decode genetics at the rate of 1,500 people per month, 400 people per week genetic decoding in the project must be from volunteers in 5 disease groups: rare diseases, cancer , NCDs, pharmacogenomics. and infectious diseases, the top 3 are rare diseases that can easily be selected by volunteers (blood must be collected from the patient and parents), cancer, and NCDs.

Target for 2025: discover the genetic code for 5 diseases

“The Genomics Thailand project is expected to complete the collection and coding of genetics for 50,000 cases in 2025. It is collecting data from patients. Create a reference database So that medical experts can make a diagnosis. Leads to efficient treatment of patients Better quality Once the genetic code is decoded The results must be returned to the patient. and providing appropriate treatment As for Level 2 operations, service standards, diagnosis and further research will be considered,” said Dr. Sisadet.

Dr. Sisadet also said that information obtained from genetic decoding in rare disease groups found about 5-8% of all patients. Although there are about 7,000 rare diseases in this group, they are therefore being discovered to provide appropriate treatment.

In cancer the goal is diagnosis. Analysis of mutations To show that there is a risk of cancer as well as NCDs, it is an assessment. Diagnose the genetic code To study the diseases that are at risk for NCDs and how to prevent them from occurring. It will detect the risk of genes that cause severe drug allergies. To avoid getting medicine and infectious diseases, check the relationship between people with disease. with germs that infect humans

Genome Center in Thailand Each center has different goals. Because the readiness of each center varies according to customer groups. People who come to use services in each hospital Medical services at the Genome Center are based on the availability of specialists. Including medical equipment devices Encoding the genetic code or data analysis technology

who hasGenome Center More and more numbers It’s a good thing. Because knowing your own genetic code can prevent, diagnose and treat various diseases. get better Reduce the cost burden of medical services. and create peace of mind for patients and families, promoting medical services, genome centers, genetic coding It is an issue that should receive more support.

Medical Genome Centre, Ramathibodi Hospital

They can support NIPT testing on around 6,000 samples per year. and can support whole human genome sequencing of 2,000 samples per year From pre-birth to seniors To live a long, healthy, quality life

For example, providing genetic testing services to married couples before they have children. Screening for carriers of over 600 recessive genetic diseases, covering severe life-threatening and disabling diseases. To reduce hereditary diseases in the Thai population, choose embryos (the result of mixing eggs and sperm in a laboratory) that are genetically complete. Moving back to the woman’s uterus (Pre-implantation genetic test: PGT) to increase the chance of pregnancy in those with infertility. Includes screening for mutant genes to prevent them from being passed on to children.

Center for Genome Medicine Bumrungrad Hospital

Center for Genome Medicine Bumrungrad Hospital is one of the first private hospitals. which has been confirmed by the Ministry of Public Health Preventive genetic analysis to detect the risk of developing disease, which covers 4 main groups: cancer, heart disease, and prenatal genetic testing. Pharmacogenetics and Precision Medicine

Currently, the genetic code is being studied in depth byEncoding the genetic codeof every gene in humans (Whole Exome Sequence) which helps to find genes in inexplicable genetic diseases. Helps to screen and prevent the risk of genetically inherited diseases.

Innovation is now being introduced. “Gene testing to select personalized medicine” or what is called “Pharmacogenomics and Precision Medicine” is used to care for patients and those receiving services. To reduce the risk of drug allergies Including so that the doctor can prescribe the correct amount of medication. and achieve maximum efficiency for each patient

Center of Medical Excellence in Genomics and Precision Medicine, Chulalongkorn Hospital

Expanded from the Center of Medical Excellence in Medical Genetics By developing and expanding patient services through the use of technology. Next Generation Sequencing (NGS) or genetic decoding technology, including Whole Exome Sequencing and Whole Genome Sequencing, has been used in many medical fields. Whether it is in the areas of diagnosis, care, prevention and health promotion. This is one of the first hospitals in the country to start using this method.

Center of Medical Excellence in Genomics and Precision Medicine We received permission to establish on September 2, 2019 by expanding work to cover systematic care services for patients with genetic diseases. Create knowledge and innovation in genomics and precision medicine Develop and train staff in the field of genomic medicine. This is to give patients access to a diagnosis. Very effective care with low side effects, equally and thoroughly Including disease prevention for the good health of the people.